Carmel, 18, St. Francis Avenue, Off S.V. Road, Santacruz (West), Mumbai-400054, Maharashtra, India.
CNS Neurol Disord Drug Targets. 2010 Mar;9(1):45-9. doi: 10.2174/187152710790966696.
Alcohol dependence is a major health problem worldwide. Various pharmacological agents have been used in the management of alcohol dependence. This review looks at the role of topiramate and other anticonvulsants in the management of alcohol dependence. Topiramate is the most widely used anticonvulsant in the treatment of alcohol dependence. The literature on topiramate is reviewed and critically analyzed, along with its proposed mechanism of action in alcohol dependence. A review of data available on other anticonvulsants like carbamazepine, oxcarbazepine, sodium valproate, gabapentin and levetiracetam are presented and their potential in the treatment of alcohol dependence is considered, together with future research directions.
酒精依赖是全球范围内的一个主要健康问题。已经有多种药理学药物被用于酒精依赖的治疗。本综述探讨了托吡酯和其他抗惊厥药物在酒精依赖治疗中的作用。托吡酯是治疗酒精依赖最广泛使用的抗惊厥药物。本文对托吡酯的文献进行了综述和批判性分析，以及其在酒精依赖中的作用机制。还对卡马西平、奥卡西平、丙戊酸钠、加巴喷丁和左乙拉西坦等其他抗惊厥药物的数据进行了回顾，并考虑了它们在治疗酒精依赖方面的潜力，以及未来的研究方向。
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