Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Int J Urol. 2010 Apr;17(4):332-6. doi: 10.1111/j.1442-2042.2010.02468.x. Epub 2010 Feb 25.
To investigate the incidence of skeletal-related events (SRE) in urological cancer patients with bone metastases in Japan.
Five hundred eleven patients with urological cancer and documented bone metastases treated from January 2003 to April 2008 in ten Japanese institutions were included in a retrospective analysis. Type and incidence of SRE (fracture, radiotherapy, spinal cord compression, surgery, hypercalcemia, and bone pain) were determined from patient medical records.
The overall incidence of SRE, including 'pain', was 61%. The most common event was radiotherapy for bone metastases, with an incidence of 31%. The overall incidence of events seemed to be similar among Japanese and Western patients with prostate cancer and renal cell carcinoma when comparing data with previously published reports. Nevertheless, a much lower incidence of fracture (19.1%) was observed in Japanese renal cell carcinoma patients.
The overall incidence of SRE in Japanese urological cancer patients with bone metastasis was similar to that in Western patients, but the incidence of fracture was lower in Japanese renal cancer patients.
调查日本骨转移泌尿癌症患者骨骼相关事件（SRE）的发生率。
对 2003 年 1 月至 2008 年 4 月在日本 10 家机构接受治疗的 511 例有骨转移记录的泌尿癌症患者进行回顾性分析。从患者病历中确定 SRE（骨折、放疗、脊髓压迫、手术、高钙血症和骨痛）的类型和发生率。
SRE（包括“疼痛”）的总发生率为 61%。最常见的事件是骨转移的放疗，发生率为 31%。与之前发表的报告相比，当比较日本和西方前列腺癌和肾细胞癌患者的数据时，似乎日本患者中所有类型事件的总发生率相似。然而，日本肾细胞癌患者的骨折发生率（19.1%）明显较低。
日本骨转移泌尿癌症患者的 SRE 总发生率与西方患者相似，但日本肾癌患者的骨折发生率较低。
