Joseph I B, Sridaran R
Department of Physiology, Morehouse School of Medicine, Atlanta, GA 30310-1495.
Life Sci. 1991;48(18):1751-6. doi: 10.1016/0024-3205(91)90212-t.
Continuous administration of a GnRH agonist (GnRH-Ag) at a dose of 5 micrograms/day, commencing on day 7 of pregnancy resulted in the suppression of daily nocturnal surges of prolactin (PRL) on day 8, and serum progesterone (P4) levels with subsequent termination of pregnancy. Replacement with dydrogesterone, a synthetic analog of P4 at a dose of 4 mg/day s.c. restored the magnitude of nocturnal PRL surges. These data suggest that GnRH-Ag may act either at the level of the brain to suppress the nocturnal PRL surge, resulting in a fall in serum P4 levels or at the level of the corpus luteum itself or at both sites simultaneously to terminate pregnancy.
从妊娠第7天开始，以每天5微克的剂量持续给予促性腺激素释放激素激动剂（GnRH-Ag），导致第8天催乳素（PRL）每日夜间高峰受到抑制，血清孕酮（P4）水平随之下降，随后妊娠终止。以每天4毫克的剂量皮下注射P4的合成类似物炔诺孕酮进行替代，恢复了夜间PRL高峰的幅度。这些数据表明，GnRH-Ag可能在大脑水平起作用以抑制夜间PRL高峰，导致血清P4水平下降，或者在黄体本身水平起作用，或者同时在这两个部位起作用以终止妊娠。
