Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, St Vincent's Hospital, Darlinghurst, Sydney, New South Wales (NSW), Australia.
Trends Endocrinol Metab. 2010 Jul;21(7):411-8. doi: 10.1016/j.tem.2010.02.004. Epub 2010 Mar 2.
The hypothalamus regulates the skeleton and adipose tissue via endocrine mechanisms. Changes in sex steroid levels in menopause and aging are central to the associated changes in bone mass and adiposity. Whereas many of these effects occur via direct actions on osteoblasts or adipocytes, sex hormones can also mediate effects on bone and adipose tissue via interaction with neuronal pathways. A key hypothalamic regulator of bone and adipose tissue is neuropeptide Y (NPY), which coordinately influences these tissues via effects on neuroendocrine and sympathetic nervous output. Better understanding of the interaction between NPY and sex steroids in regulating skeletal and energy homeostasis could lead to more effective treatments for osteoporosis and obesity.
下丘脑通过内分泌机制调节骨骼和脂肪组织。绝经和衰老过程中性类固醇水平的变化是与骨量和脂肪量相关变化的核心。虽然这些作用中的许多是通过对成骨细胞或脂肪细胞的直接作用发生的，但性激素也可以通过与神经元途径的相互作用来介导对骨骼和脂肪组织的作用。神经肽 Y（NPY）是调节骨骼和脂肪组织的关键下丘脑调节剂，它通过对神经内分泌和交感神经输出的影响协调地影响这些组织。更好地了解 NPY 和性激素在调节骨骼和能量平衡方面的相互作用可能会导致更有效的骨质疏松症和肥胖症治疗方法。
