Pierce Brandon L, Ahsan Habibul
Department of Health Studies, The University of Chicago, Chicago, IL 60637, USA.
Hum Hered. 2010;69(3):193-201. doi: 10.1159/000289594. Epub 2010 Mar 5.
To examine the collective effects of type 1 (T1D) and type 2 diabetes (T2D) risk alleles on prostate cancer (PCa) risk.
Using data on 14 and 18 single nucleotide polymorphisms (SNPs) that effect T1D and T2D risk, respectively, we generated risk scores (a 'risk allele count' and a 'genetic relative risk') for both T1D and T2D for 1,171 non-Hispanic white, PSA-screened PCa cases and 1,101 matched controls from the Cancer Genetic Markers of Susceptibility study. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for associations between the diabetes risk scores and PCa risk.
Both T2D risk scores, but neither T1D score, showed an inverse association with PCa (p < 0.01). These associations remained significant after excluding HNF1B SNP rs4430796 (a known PCa risk factor) from the analysis. The highest quartile of the T2D allele count (>20 risk alleles) was associated with reduced PCa risk (OR = 0.77; CI: 0.60-0.99) compared to the lowest category (<17 risk alleles).
These results suggest that individuals with increased genetic susceptibility to T2D have decreased risk for PCa. This association is consistent with the observation that individuals with T2D are at decreased risk for PCa; however, data on T2D status was not available for this analysis.
研究1型糖尿病（T1D）和2型糖尿病（T2D）风险等位基因对前列腺癌（PCa）风险的综合影响。
利用分别影响T1D和T2D风险的14个和18个单核苷酸多态性（SNP）数据，我们为癌症遗传易感性研究中的1171名非西班牙裔白人PSA筛查PCa病例和1101名匹配对照生成了T1D和T2D的风险评分（“风险等位基因计数”和“遗传相对风险”）。采用逻辑回归估计糖尿病风险评分与PCa风险之间关联的比值比（OR）和95%置信区间（CI）。
两个T2D风险评分均与PCa呈负相关（p<0.01），而两个T1D评分均未显示出这种相关性。在分析中排除HNF1B SNP rs4430796（一种已知的PCa风险因素）后，这些关联仍然显著。与最低类别（<17个风险等位基因）相比，T2D等位基因计数最高四分位数（>20个风险等位基因）与PCa风险降低相关（OR = 0.77；CI：0.60 - 0.99）。
这些结果表明，对T2D遗传易感性增加的个体患PCa的风险降低。这种关联与T2D个体患PCa风险降低的观察结果一致；然而，本分析中没有T2D状态的数据。
