Frayling T M, Colhoun H, Florez J C
Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, UK.
Diabetologia. 2008 Oct;51(10):1757-60. doi: 10.1007/s00125-008-1114-9. Epub 2008 Aug 12.
Epidemiological studies suggest that men with type 2 diabetes are less likely than non-diabetic men to develop prostate cancer. The cause of this association is not known. Recent genetic studies have highlighted a potential genetic link between the two diseases. Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. Other, separate, studies have identified different variants in the JAZF1 gene, one associated with type 2 diabetes, another associated with prostate cancer. These findings are unlikely to completely explain the epidemiological association between the two diseases but they provide new insight into a possible direct causal link, rather than one that is confounded or biased in some way.
流行病学研究表明，2型糖尿病男性患前列腺癌的可能性低于非糖尿病男性。这种关联的原因尚不清楚。最近的基因研究突出了这两种疾病之间潜在的基因联系。两项研究已经确定了HNF1B（也称为TCF2）基因中的一个变异体的一个版本（等位基因），该等位基因易患2型糖尿病，其中一项研究表明，同一个等位基因可保护男性免受前列腺癌的侵害。其他独立研究在JAZF1基因中发现了不同的变异体，一个与2型糖尿病有关，另一个与前列腺癌有关。这些发现不太可能完全解释这两种疾病之间的流行病学关联，但它们为可能的直接因果联系提供了新的见解，而不是以某种方式混淆或有偏差的联系。
