Bruckner A P
Appl Opt. 1978 Oct 1;17(19):3177-83. doi: 10.1364/AO.17.003177.
A picosecond range-gated light scattering technique is used to measure the microstructure of cataracts in the living eye, with a resolution of the order of the wavelength of light. The cataract is illuminated with ultrashort pulses of light derived from a mode-locked Nd:glass laser. The pulses backscattered by the opacity are collected at several angles simultaneously by an array of fiber-optic light guides whose outputs are sequentially sampled by a multichannel picosecond Kerr shutter. This shutter transmits only that light which is scattered from the desired depth in the eye, while blocking from the detector any light scattered by foreground or background tissue and reducing multiple scattering effects. The size distribution of scatterers in the cataract is deduced from the angular distribution of scattering intensities by application of Mie theory. The results of experiments with suspensions of latex microspheres and with rabbit cataracts in vivo are presented. Cataract microstructure down to 0.5 microm has been measured in a rabbit eye and verified with electron microscopy.
一种皮秒范围选通光散射技术被用于测量活眼中白内障的微观结构，分辨率达到光波长量级。用锁模钕玻璃激光器产生的超短光脉冲照射白内障。由不透明体反向散射的脉冲由光纤光导阵列同时在几个角度收集，其输出由多通道皮秒克尔快门顺序采样。该快门只透射从眼睛中所需深度散射的光，同时阻挡探测器接收由眼前景或背景组织散射的任何光，并减少多重散射效应。通过应用米氏理论，从散射强度的角分布推导出白内障中散射体的尺寸分布。给出了乳胶微球悬浮液和兔白内障活体实验的结果。在兔眼中测量到了低至0.5微米的白内障微观结构，并通过电子显微镜进行了验证。
