Department of Pharmacy, China Medical University, Taichung, Taiwan.
Ann Surg Oncol. 2010 Jun;17(6):1675-81. doi: 10.1245/s10434-010-0994-3. Epub 2010 Mar 4.
Bone metastases are the most critical complication of prostate cancer (PCa), resulting in severe morbidity and mortality. Tumor necrosis factor receptor superfamily member 11b (TNFRSF11B) is a critical regulator between PCa cells and the bone environment. Recently, TNFRSF11B rs10505346 has been implicated in PCa risk in the Cancer Genetic Markers of Susceptibility genomewide association study. However, the association between this variant and biochemical failure in PCa patients receiving radical prostatectomy (RP) has not been determined.
Associations of TNFRSF11B rs10505346 with age at diagnosis, preoperative prostate-specific antigen (PSA) level, Gleason score, pathologic stage, surgical margin, and PSA recurrence were evaluated in a cohort of 314 localized PCa patients receiving RP. The prognostic significance on PSA recurrence was assessed by Kaplan-Meier analysis and Cox regression model.
The mean level of preoperative PSA and the relative risks of PSA recurrence after RP were lower in individuals with T allele than in those with the G allele at TNFRSF11B rs10505346 (P = 0.019 and 0.014, respectively). The T allele of rs10505346 remained a protective factor against PSA recurrence (P = 0.022) in multivariate Cox regression model after considering all clinicopathological risk factors except PSA level.
Our data suggest that TNFRSF11B rs10505346 is associated with PSA level and might be a prognostic factor for the recurrence of PSA in PCa patients receiving RP.
骨转移是前列腺癌（PCa）最严重的并发症，导致严重的发病率和死亡率。肿瘤坏死因子受体超家族成员 11b（TNFRSF11B）是 PCa 细胞与骨环境之间的关键调节因子。最近，TNFRSF11B rs10505346 已被牵连到癌症遗传标记物易感全基因组关联研究中的 PCa 风险中。然而，该变体与接受根治性前列腺切除术（RP）的 PCa 患者生化失败之间的关联尚未确定。
在接受 RP 的 314 例局部 PCa 患者队列中，评估了 TNFRSF11B rs10505346 与诊断时年龄、术前前列腺特异性抗原（PSA）水平、Gleason 评分、病理分期、手术切缘和 PSA 复发之间的关联。通过 Kaplan-Meier 分析和 Cox 回归模型评估 PSA 复发的预后意义。
与 TNFRSF11B rs10505346 的 G 等位基因相比，T 等位基因个体的术前 PSA 水平平均值和 RP 后 PSA 复发的相对风险较低（P = 0.019 和 0.014）。在考虑除 PSA 水平以外的所有临床病理危险因素的多变量 Cox 回归模型中，rs10505346 的 T 等位基因仍然是 PSA 复发的保护因素（P = 0.022）。
我们的数据表明，TNFRSF11B rs10505346 与 PSA 水平相关，并且可能是接受 RP 的 PCa 患者 PSA 复发的预后因素。
