University of Giessen Lung Center (UGLC), Justus-Liebig-University Giessen, Giessen, Germany.
Adv Exp Med Biol. 2010;661:187-200. doi: 10.1007/978-1-60761-500-2_12.
Hypoxic pulmonary vasoconstriction (HPV) is an essential mechanism of the lung matching blood perfusion to ventilation during local alveolar hypoxia. HPV thus optimizes pulmonary gas exchange. In contrast chronic and generalized hypoxia leads to pulmonary vascular remodeling with subsequent pulmonary hypertension and right heart hypertrophy. Among other non-selective cation channels, the family of classical transient receptor potential channels (TRPC) has been shown to be expressed in pulmonary arterial smooth muscle cells. Among this family, TRPC6 is essential for the regulation of acute HPV in mice. Against this background, in this chapter we give an overview about the TRPC family and their role in HPV.
低氧性肺血管收缩（HPV）是肺在局部肺泡缺氧时将血液灌注与通气相匹配的重要机制。HPV 因此优化了肺气体交换。相比之下，慢性和全身性缺氧会导致肺血管重塑，随后出现肺动脉高压和右心肥大。在其他非选择性阳离子通道中，经典瞬时受体电位通道（TRPC）家族已被证明在肺动脉平滑肌细胞中表达。在这个家族中，TRPC6 对于调节小鼠的急性 HPV 是必不可少的。在此背景下，在本章中，我们概述了 TRPC 家族及其在 HPV 中的作用。
