Departments of Thoracic Surgery, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Adv Exp Med Biol. 2010;662:115-20. doi: 10.1007/978-1-4419-1241-1_16.
To investigate age-related changes in the shape of trachea, normal male volunteers (n = 83, mean +/- SD: 47.7 +/- 20.2 years old) underwent inspiratory CT scans at full inspiration and lung function tests. Subjects who showed VC < 80% predicted or FEV1 < 80% predicted on lung function tests were excluded. The CT data, which is located at 2.0 cm above the aortic arch, were transferred to a personal computer. The tracheal area (St) and two parameters, Tracheal index (Ti) and Circularity (Ci) indicating the shape of the trachea, were automatically calculated. Ti was defined the ratio of the coronal to the sagittal diameter of the trachea, and the Ci (Ci = 4piS/L2, S: tracheal area, L: tracheal perimeter) was used to indicate the roundness of the trachea. A Ci value of less than 1 indicated the distortion of the roundness. Both St and St/BSA (body surface area) showed a significant correlation with age (r = 0.37, r = 0.52; p = 0.0006, p < 0.0001). Ti was not correlated with age (r = -0.20; p = 0.0697), whereas Ci was significantly correlated with age (r = -0.32; p = 0.00364). There were measurable age related changes of the trachea both in the area and the shape. Aging results in the increased tracheal area and a distortion of the roundness.
为了研究气管形状与年龄的相关性变化，我们对 83 名正常男性志愿者（平均年龄为 47.7±20.2 岁）进行了吸气 CT 扫描和肺功能检查。排除了肺活量（VC）低于预计值 80%或 1 秒用力呼气量（FEV1）低于预计值 80%的受试者。将 CT 数据（位于主动脉弓上方 2.0cm 处）传输到个人电脑。自动计算气管面积（St）和两个参数，即表示气管形状的气管指数（Ti）和圆度（Ci）。Ti 定义为气管冠状径与矢状径的比值，Ci（Ci=4piS/L2，S：气管面积，L：气管周长）用于表示气管的圆度。Ci 值小于 1 表示圆度变形。St 和 St/BSA（体表面积）均与年龄呈显著相关性（r=0.37，r=0.52；p=0.0006，p<0.0001）。Ti 与年龄无相关性（r=-0.20；p=0.0697），而 Ci 与年龄呈显著相关性（r=-0.32；p=0.00364）。气管的面积和形状都发生了可测量的与年龄相关的变化。随着年龄的增长，气管面积增大，圆度变形。
