De Martinis Massimo, Sirufo Maria Maddalena, Ginaldi Lia
Department of Life, Health, & Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Aging Dis. 2017 Apr 1;8(2):162-175. doi: 10.14336/AD.2016.0831. eCollection 2017 Apr.
Allergy reactions are the most common immunological diseases and represent one of the most widespread and fast growing chronic human health problems among people over 15 years of age in developed countries. As populations get older worldwide, allergy manifestations in aged persons will occur more often in the future. To date, there has been much more studies on allergies in children than in adults. As the population ages, clinicians must be prepared to meet all the elderly's health care needs, including these new and emerging health issue. Allergic diseases represent an old/new emerging health issue. Because many common illnesses masquerade as atopic disease, the differential diagnosis of suspected allergic diseases becomes more expanded in an aging population. Research in the field needs to focus on both human and animal model systems to investigate the impact of the aging process on the immunologic pathways underpinning allergy and its different facets.
过敏反应是最常见的免疫性疾病，是发达国家15岁以上人群中最普遍且快速增长的慢性人类健康问题之一。随着全球人口老龄化，未来老年人中过敏表现将更频繁出现。迄今为止，关于儿童过敏的研究比成人多得多。随着人口老龄化，临床医生必须准备好满足老年人所有的医疗保健需求，包括这些新出现的健康问题。过敏性疾病是一个新出现的老健康问题。由于许多常见疾病会伪装成特应性疾病，在老龄化人群中，疑似过敏性疾病的鉴别诊断范围变得更广。该领域的研究需要聚焦于人类和动物模型系统，以研究衰老过程对构成过敏及其不同方面基础的免疫途径的影响。
