UZ Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.
Adv Exp Med Biol. 2010;662:461-6. doi: 10.1007/978-1-4419-1241-1_66.
The cerebral tissue oxygenation index (TOI) and fractional tissue oxygen extraction (FTOE) reflect the cerebral oxygenation. We studied the effect of glycaemia on the TOI and FTOE, as measured by near-infrared-spectroscopy (NIRS). We continuously measured TOI, glycaemia, mean arterial blood pressure (MABP), saturation (SaO(2)) and transcutaneous carbon dioxide pressure (tPCO(2)) for at least 4 h during the first week of life in neonates with gestational age (GA) < 32 weeks and weight < 1500 g. FTOE was calculated. 24 measurements in 11 neonates were analyzed. We found a significant negative correlation (r = -0.077; p = 0.0344) between glycaemia and TOI, also after correction for MABP, SaO(2) and tPCO(2) (r = -0.118; p = 0.002) and a significant positive correlation between glycaemia and FTOE (r = 0.147; p < 0.000) which remained significant after correction for MABP and tPCO(2) (r = 0.116; p = 0.001). Our results indicate that in neonates during the first days of life glycaemia - even within the normal ranges and after correction for MABP, SaO(2) and tPCO(2) - influences the cerebral oxygenation.
脑组织氧合指数 (TOI) 和组织氧摄取分数 (FTOE) 反映了脑氧合情况。我们通过近红外光谱 (NIRS) 研究了血糖对 TOI 和 FTOE 的影响。我们连续测量了至少 4 小时的 TOI、血糖、平均动脉血压 (MABP)、饱和度 (SaO(2)) 和经皮二氧化碳分压 (tPCO(2))，这些数据来自胎龄 (GA) < 32 周且体重 < 1500 g 的新生儿。并计算了 FTOE。我们分析了 11 名新生儿的 24 次测量。我们发现血糖与 TOI 之间存在显著的负相关关系 (r = -0.077; p = 0.0344)，即使在校正了 MABP、SaO(2) 和 tPCO(2) 后也是如此 (r = -0.118; p = 0.002)，而且血糖与 FTOE 之间存在显著的正相关关系 (r = 0.147; p < 0.000)，即使在校正了 MABP 和 tPCO(2 后仍有显著相关性 (r = 0.116; p = 0.001)。我们的结果表明，在新生儿生命的最初几天，血糖 - 即使在正常范围内，并且校正了 MABP、SaO(2) 和 tPCO(2) - 也会影响脑氧合。
