一种生产抗疟原虫疫苗的有效方法。
An efficient approach to the production of vaccines against the malaria parasite.
作者信息
Tsuboi Takafumi, Takeo Satoru, Sawasaki Tatsuya, Torii Motomi, Endo Yaeta
机构信息
Cell-Free Science and Technology Research Center and Venture Business Laboratory, Ehime University, Ehime, Japan.
出版信息
Methods Mol Biol. 2010;607:73-83. doi: 10.1007/978-1-60327-331-2_8.
In malaria vaccine research, one of the major obstacles has been the difficulty of expressing recombinant malarial proteins and it is mainly due to the lack of an efficient methodology for the synthesis of sufficient quantity of quality proteins. We demonstrate that the wheat germ cell-free protein synthesis system can be applied for the successful production of leading malaria vaccine candidate antigens and, thus, prove that it may be a key tool for malaria vaccine research.
在疟疾疫苗研究中，主要障碍之一是表达重组疟原虫蛋白存在困难，这主要是由于缺乏一种有效的方法来合成足够数量的高质量蛋白。我们证明，小麦胚无细胞蛋白质合成系统可用于成功生产主要的疟疾疫苗候选抗原，因此，证明它可能是疟疾疫苗研究的关键工具。
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