Birnbaum Gary
Multiple Sclerosis Treatment and Research Center, Minneapolis Clinic of Neurology, Golden Valley, MN 55422, USA.
Curr Opin Drug Discov Devel. 2010 Mar;13(2):214-25.
The last decades of the twentieth century ushered in the first treatments proven to modify the disease course of multiple sclerosis (MS). These breakthroughs in MS therapy stimulated an increase in the search for drugs with improved efficacy and greater ease of administration. This review summarizes the latest developments in the search for improved disease-modifying therapies and defines the efficacies and potential risks of such compounds. As with all new drugs, accurate assessments of risk:benefit ratios will be essential for the successful use of any agent targeting MS.
二十世纪的最后几十年迎来了首批经证实可改变多发性硬化症(MS)病程的治疗方法。MS治疗领域的这些突破促使人们加大了对疗效更佳、给药更便捷药物的探索力度。本综述总结了在寻找改良疾病修正疗法方面的最新进展,并明确了此类化合物的疗效和潜在风险。与所有新药一样,准确评估风险效益比对于成功使用任何针对MS的药物至关重要。