Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Mol Nutr Food Res. 2010 May;54(5):616-22. doi: 10.1002/mnfr.200900481.
Vitamin E is an essential fat-soluble micronutrient for higher mammals and functions as an antioxidant for lipids and also as a regulator of gene expression and a modulator of cell signaling and proliferation. To exert its physiological functions, vitamin E must achieve an appropriate disposition throughout the body via several processes, such as intestinal absorption, uptake and efflux in peripheral tissues and biliary secretion. In this review, we mainly discuss membrane proteins involved in these transport processes (ATP-binding cassette transporter A1, scavenger receptor class B type I, Niemann-Pick C1-like 1 and multidrug resistance 3) and vitamin E-mediated regulation of their expression.
维生素 E 是高等哺乳动物必需的脂溶性微量营养素，具有抗氧化脂质、调节基因表达、调控细胞信号转导和增殖等功能。为了发挥其生理功能，维生素 E 必须通过几种过程在全身达到适当的分布，如肠道吸收、外周组织摄取和流出以及胆汁分泌。在这篇综述中，我们主要讨论了参与这些转运过程的膜蛋白（ATP 结合盒转运蛋白 A1、清道夫受体 B 类 I、尼曼-匹克 C1 样 1 和多药耐药蛋白 3）和维生素 E 对其表达的调节。
