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Antigen-antibody interactions at the molecular level: adventures in peptide synthesis.分子水平上的抗原-抗体相互作用：肽合成的探索
Immunol Today. 1985 Dec;6(12):364-9. doi: 10.1016/0167-5699(85)90096-9.
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Butenolide induced cytotoxicity by disturbing the prooxidant-antioxidant balance, and antioxidants partly quench in human chondrocytes.丁烯内酯通过扰乱促氧化剂-抗氧化剂平衡诱导细胞毒性，且抗氧化剂可部分消除人软骨细胞中的这种毒性。
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Antibodies and immunohistochemistry in extracellular matrix research.细胞外基质研究中的抗体与免疫组织化学
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Oxidative stress induces expression of osteoarthritis markers procollagen IIA and 3B3(-) in adult bovine articular cartilage.氧化应激诱导成年牛关节软骨中骨关节炎标志物IIA型前胶原蛋白和3B3(-)的表达。
Osteoarthritis Cartilage. 2008 Jun;16(6):698-707. doi: 10.1016/j.joca.2007.10.004. Epub 2008 Feb 6.
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Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect.T-2毒素对关节软骨蛋白聚糖降解的促进作用及硒的保护作用。
J Zhejiang Univ Sci B. 2008 Jan;9(1):22-33. doi: 10.1631/jzus.B071322.
6
Articular cartilage metabolism in patients with Kashin-Beck Disease: an endemic osteoarthropathy in China.大骨节病患者的关节软骨代谢：中国的一种地方性骨关节炎
Osteoarthritis Cartilage. 2008 Jun;16(6):680-8. doi: 10.1016/j.joca.2007.09.002. Epub 2007 Oct 22.
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Control of matrix metalloproteinase catalytic activity.基质金属蛋白酶催化活性的调控
Matrix Biol. 2007 Oct;26(8):587-96. doi: 10.1016/j.matbio.2007.07.001. Epub 2007 Jul 7.
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MMP and non-MMP-mediated release of aggrecan and its fragments from articular cartilage: a comparative study of three different aggrecan and glycosaminoglycan assays.基质金属蛋白酶（MMP）和非MMP介导的蛋白聚糖及其片段从关节软骨中的释放：三种不同蛋白聚糖和糖胺聚糖检测方法的比较研究
Osteoarthritis Cartilage. 2007 Feb;15(2):212-21. doi: 10.1016/j.joca.2006.07.009. Epub 2006 Sep 25.
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Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage.II型胶原蛋白肽可诱导关节软骨中II型胶原蛋白和聚集蛋白聚糖的裂解。
Matrix Biol. 2006 Sep;25(7):419-29. doi: 10.1016/j.matbio.2006.06.004. Epub 2006 Jun 30.
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Demineralized bone matrix gelatin as scaffold for osteochondral tissue engineering.脱矿骨基质明胶作为骨软骨组织工程的支架材料。
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玉米赤霉烯酮和硒对人关节软骨代谢的影响及其与大骨节病发病机制的潜在关系。

Effects of moniliformin and selenium on human articular cartilage metabolism and their potential relationships to the pathogenesis of Kashin-Beck disease.

机构信息

Institute of Endemic Diseases, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.

出版信息

J Zhejiang Univ Sci B. 2010 Mar;11(3):200-8. doi: 10.1631/jzus.B0900074.

DOI:10.1631/jzus.B0900074
PMID:20205306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2833404/
Abstract

OBJECTIVE

To investigate the effects of mycotoxin moniliformin (MON) on the metabolism of aggrecan and type II collagen in human chondrocytes in vitro and the relationship between MON and Kashin-Beck disease (KBD).

METHODS

Human chondrocytes were isolated and cultured on bone matrix gelatin to form an artificial cartilage model in vitro with or without MON toxin. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The expression of aggrecan and type II collagen in the cartilage was determined using immunocytochemical staining.

RESULTS

MON toxin inhibited chondrocyte viability in dose-dependent and time-dependent manners. MON reduced aggrecan and type II collagen syntheses in the tissue-engineered cartilage. MON also increased the expression of matrix metalloproteinase-1 (MMP-1), MMP-13, BC4 epitopes, and CD44 in cartilages. However, the expression of 3B3(-) epitopes in cartilages was inhibited by MON. Selenium partially alleviated the damage of aggrecan induced by MON toxin.

CONCLUSION

MON toxin promoted the catabolism of aggrecan and type II collagen in human chondrocytes.

摘要

目的

研究真菌毒素玉米赤霉烯酮（MON）对体外人软骨细胞中聚集蛋白聚糖和 II 型胶原代谢的影响，以及 MON 与大骨节病（KBD）的关系。

方法

采用骨基质明胶体外培养人软骨细胞，构建人工软骨模型，分别加入或不加入 MON 毒素。通过 3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐（MTT）比色法检测细胞活力。免疫细胞化学染色法检测软骨中聚集蛋白聚糖和 II 型胶原的表达。

结果

MON 毒素呈剂量和时间依赖性抑制软骨细胞活力。MON 减少组织工程软骨中聚集蛋白聚糖和 II 型胶原的合成。MON 还增加了软骨中基质金属蛋白酶-1（MMP-1）、MMP-13、BC4 表位和 CD44 的表达，但抑制了软骨中 3B3(-)表位的表达。硒部分缓解了 MON 毒素诱导的聚集蛋白聚糖损伤。

结论

MON 毒素促进了人软骨细胞中聚集蛋白聚糖和 II 型胶原的分解代谢。