Department of Obstetrics and Gynecology, Sherbrooke University Hospital Centre, 3001, 12e Avenue Nord, Sherbrooke, Quebec, J1H 5N4 Canada.
J Ovarian Res. 2010 Jan 19;3:2. doi: 10.1186/1757-2215-3-2.
Endometriosis has been believed to increase the risk of developing ovarian cancer, but recent data supporting this hypothesis are lacking. The aim of this study was to verify whether the incidence of endometriosis, ovarian cancer and the both increased during the last 10 years among women living in the Estrie region of Quebec.
We collected data of women diagnosed with endometriosis, ovarian cancer or both, between 1997 and 2006, from a population living in the Estrie region of Quebec. We performed this retrospective cross-sectional study from the CIRESSS (Centre Informatisé de Recherche Evaluative en Services et Soins de Santé) system, the database of the CHUS (Centre Hospitalier Universitaire of Sherbrooke), Sherbrooke, Canada.
Among the 2854 identified patients, 2521 had endometriosis, 292 patients had ovarian cancer and 41 patients had both ovarian cancer and endometriosis. We showed a constant increase in the number of ovarian cancer (OC) between 1997 and 2006 (r2 = 0.557, P = 0.013), which is not the case for endometriosis (ENDO) or endometriosis-associated ovarian cancer (EAOC). The mean age +/- SD was 40.0 +/- 9.9 and 53.9 +/- 11.4 for patients having ENDO and OC, respectively. Mean age of women with EAOC was 48.3 +/- 10.8, suggesting an early onset of ovarian cancer in women having endometriosis of about 5.5 years average, P = 0.003. Women with ENDO were at increased risk for developing OC (Rate Ratio [RR] = 1.6; 95% Confidence Interval [CI] = 1.12-2.09). Pathological analyses showed the predominance of endometrioid type (24.4%) and clear-cell type (21.9%) types in EAOC compared to OC, P = 0.0070 and 0.0029, respectively. However, the serous type is the most widespread in OC (44.5%) in comparison to EAOC (19.51%), P = 0.0023.
Our findings highlight that the number of cases of ovarian cancer is constantly increasing in the last ten years and that endometriosis represents a serious risk factor which accelerates its apparition by about 5.5 years.
人们一直认为子宫内膜异位症会增加患卵巢癌的风险，但目前缺乏支持这一假设的最新数据。本研究旨在验证魁北克 Estrie 地区女性在过去 10 年中子宫内膜异位症、卵巢癌和两者的发病率是否增加。
我们从加拿大舍布鲁克 CHUS（舍布鲁克大学医院）的 CIRESSS（卫生服务和医疗保健评估信息研究中心）系统收集了 1997 年至 2006 年间诊断为子宫内膜异位症、卵巢癌或两者的女性的数据。我们对这些数据进行了回顾性横断面研究。
在确定的 2854 名患者中，2521 名患有子宫内膜异位症，292 名患有卵巢癌，41 名患有卵巢癌和子宫内膜异位症。我们发现，卵巢癌的数量在 1997 年至 2006 年间呈持续增加（r2=0.557，P=0.013），而子宫内膜异位症或子宫内膜异位症相关卵巢癌则不是如此。患有子宫内膜异位症和卵巢癌的患者的平均年龄分别为 40.0±9.9 和 53.9±11.4。患有子宫内膜异位症相关卵巢癌的女性的平均年龄为 48.3±10.8，这表明患有子宫内膜异位症的女性患卵巢癌的发病年龄提前了约 5.5 年，P=0.003。患有子宫内膜异位症的女性患卵巢癌的风险增加（率比 [RR]=1.6；95%置信区间 [CI]=1.12-2.09）。病理分析显示，与卵巢癌相比，子宫内膜异位症相关卵巢癌中以子宫内膜样型（24.4%）和透明细胞型（21.9%）为主，P=0.0070 和 0.0029。然而，与子宫内膜异位症相关卵巢癌（19.51%）相比，浆液型在卵巢癌中更为常见（44.5%），P=0.0023。
我们的研究结果表明，过去十年中卵巢癌的病例数量不断增加，而子宫内膜异位症是一个严重的危险因素，可使卵巢癌的发病提前约 5.5 年。
