Lee E Y, Stenson W F, DeSchryver-Kecskemeti K
Division of Surgical Pathology, Washington University Medical School, St. Louis, Missouri.
Mod Pathol. 1991 Jan;4(1):87-90.
Crohn's disease (CD) of the bowel showed a statistically significant thickening of the muscularis mucosae when compared with disease controls. In areas of gross stricture in CD, the muscularis mucosae comprised almost 10% of total wall thickness. Similar findings were also present in a previously characterized experimental model of CD (trinitrobenzene sulfonic acid-induced colitis in rats), particularly in what appeared to be grossly strictured areas. Taken together, these findings suggest that increased mass of muscularis mucosae smooth muscle may be responsible in part for the commonly observed stricture formation in CD. As extreme muscularis mucosae hyperplasia appears to be peculiar to CD, it may serve as an additional marker differentiating CD from other diseases.
与疾病对照组相比，肠道克罗恩病（CD）的黏膜肌层出现了具有统计学意义的增厚。在CD严重狭窄区域，黏膜肌层几乎占肠壁总厚度的10%。在先前已明确特征的CD实验模型（大鼠三硝基苯磺酸诱导的结肠炎）中也有类似发现，尤其是在明显狭窄的区域。综合这些发现表明，黏膜肌层平滑肌质量增加可能在一定程度上导致了CD中常见的狭窄形成。由于极端的黏膜肌层增生似乎是CD所特有的，它可能作为一种将CD与其他疾病区分开来的额外标志物。
