血浆镁浓度升高对新生猪脑脊液镁水平的影响。

Effects of elevated plasma magnesium concentration on cerebrospinal fluid levels of magnesium in neonatal swine.

作者信息

Rivera L I, Gootman P M, Lin R H, Gootman N

机构信息

Department of Pediatrics, Schneider Children's Hospital of the Long Island Jewish Medical Center, New Hyde Park, New York 11042.

出版信息

Proc Soc Exp Biol Med. 1991 May;197(1):98-101. doi: 10.3181/00379727-197-43231.

DOI:10.3181/00379727-197-43231

PMID:2020673

Abstract

To determine whether magnesium (Mg) can cross the blood brain barrier in developing swine, simultaneous measurements of [Mg] in plasma and cerebrospinal fluid (CSF) were made during experimental elevation of plasma [Mg] in 12 swine of differing postnatal age. All were anesthetized with Saffan and maintained at normal arterial blood gas composition. Aortic pressure and heart rate were monitored. Plasma and CSF samples, drawn at the beginning and end of a 60-min intravenous infusion of MgCl2 in all animals and every 10 min during the infusion in three, were analyzed for [Mg] and osmolality. CSF [Mg] increased in all animals as plasma [Mg] increased. There were no changes in CSF osmolality. The differences between plasma and CSF [Mg] was smallest in the youngest animals. These results indicate that Mg crosses the blood brain barrier in neonatal swine and suggest that the blood brain barrier is still maturing within the first postnatal month.

摘要

为了确定镁（Mg）是否能在发育中的猪体内穿过血脑屏障，在12只不同出生后年龄的猪中，当血浆镁浓度（[Mg]）通过实验性升高时，同时测量了血浆和脑脊液（CSF）中的[Mg]。所有猪均用舒泛（Saffan）麻醉，并维持正常的动脉血气成分。监测主动脉压力和心率。在所有动物静脉输注MgCl2 60分钟的开始和结束时采集血浆和脑脊液样本，并在三只动物输注期间每10分钟采集一次，分析其中的[Mg]和渗透压。随着血浆[Mg]升高，所有动物的脑脊液[Mg]均增加。脑脊液渗透压无变化。最年幼动物的血浆和脑脊液[Mg]差异最小。这些结果表明镁可在新生猪体内穿过血脑屏障，并提示血脑屏障在出生后的第一个月内仍在发育成熟。