Drouet A, Desjeux G, Balaire C, Thevenin-Garron V
Service de neurologie, hôpital d'instruction des armées Desgenettes, boulevard Pinel, Lyon cedex 03, France.
Rev Neurol (Paris). 2010 Jun-Jul;166(6-7):621-9. doi: 10.1016/j.neurol.2010.01.004. Epub 2010 Mar 6.
An apparent increased risk for developing Amyotrophic Lateral Sclerosis (ALS), a multifactorial neurodegenerative disease, is considered to exist in the military population.
ALS military and veteran patients were retrospectively recruited in April 2008 by searching medical data (Hippocrate) and repayment data (Erasme) of the French National Military Health Care Fund (Caisse nationale militaire de sécurité sociale, CNMSS) from de January 1991 to December 2007.
We report a series of 73 patients, 69 male and four female, average age of 52.5 years (range 27 to 72 years) with a peak of patients in the 50-59 year age class. The branch of military service was Army (n=26 patients), Air force (n=14), Navy (n=10) and State Police Force (n=22). The incidence among male active duty military personnel was stable from 2002 to 2007; it was less than the general population (1.7/100,000 per year in 2007), but higher in the 40-44 and 50-54 year age classes (1.90 and 5.07/100,000 per year in 2007 respectively). Duration of active duty was on average 31 years.
The retrospective nature of the data and the incomplete population with loss of retired military personnel without CNMSS affiliation are limitations of our study. Another means of collecting all cases of ALS among French military personnel and veterans would be to conduct a search in the 17 ALS centers in France with analysis by occupational activity for entire career.
肌萎缩侧索硬化症（ALS）是一种多因素神经退行性疾病，军人患该病的风险似乎有所增加。
2008年4月，通过检索1991年1月至2007年12月法国国家军事医疗保健基金（国家军事社会保险基金，CNMSS）的医疗数据（希波克拉底系统）和报销数据（伊拉斯谟系统），对ALS军人及退伍军人患者进行了回顾性招募。
我们报告了73例患者，其中男性69例，女性4例，平均年龄52.5岁（范围27至72岁），50 - 59岁年龄组患者人数最多。军种分支包括陆军（26例患者）、空军（14例）、海军（10例）和国家警察部队（22例）。2002年至2007年期间，男性现役军人中的发病率保持稳定；低于普通人群（2007年为每年1.7/10万），但在40 - 44岁和50 - 54岁年龄组中较高（2007年分别为每年1.90和5.07/10万）。现役平均时长为31年。
数据的回顾性性质以及未纳入无CNMSS隶属关系的退休军人这一不完整人群是我们研究的局限性。收集法国军人及退伍军人中所有ALS病例的另一种方法是在法国的17个ALS中心进行检索，并按整个职业生涯的职业活动进行分析。
