Division of Child Neurology and Psychiatry, Department of Paediatrics, University of Catania, Italy.
Eur J Paediatr Neurol. 2010 Nov;14(6):503-7. doi: 10.1016/j.ejpn.2010.02.002. Epub 2010 Mar 5.
Late-preterms represent the 70% of the whole preterm population and are reported to be at higher risk for mortality and morbidity than term infants.
To assess neurodevelopmental outcome in low-risk late-preterm infants at 12 and 18 months corrected age, to compare results of corrected and uncorrected age to those of term-born infants, to analyse the possible influence of gender on outcome.
Sixty-one healthy infants born between 33 and 36 weeks gestational age without major brain lesions were assessed at 12 and 18 months corrected age using the Bayley II scale. A control group of 60 low-risk term born infants underwent the same assessment.
At 12 and 18 months corrected age late preterms showed a mean mental developmental index (MDI) similar to term infants. Comparing the results of the uncorrected age with term infants, the scores were significantly lower at both 12 and 18 months. No gender differences were observed in term-born infants, while male late-preterm infants showed lower MDI than peer females at both ages.
When correcting age for prematurity late-preterms have similar MDI scores to those obtained in term-born infants at 12 and 18 months. In contrast, when using chronological age there is a number of infants with low MDI. As cognitive abnormalities are reported at school age in late preterm infants, our findings raise the question on whether the results obtained using scores uncorrected for age may early identify the infants who will show cognitive difficulties at school age.
晚期早产儿占所有早产儿的 70%，据报道其死亡率和发病率均高于足月儿。
评估低危晚期早产儿在 12 个月和 18 个月校正年龄时的神经发育结局，将校正年龄和未校正年龄的结果与足月儿的结果进行比较，并分析性别对结果的可能影响。
61 例胎龄在 33 至 36 周之间且无脑损伤的健康婴儿在 12 个月和 18 个月校正年龄时使用贝利 II 量表进行评估。一组 60 例低危足月出生的婴儿进行了相同的评估。
在 12 个月和 18 个月校正年龄时，晚期早产儿的精神发育指数（MDI）与足月儿相似。与足月儿的未校正年龄相比，校正年龄和未校正年龄的评分在 12 个月和 18 个月时均显著降低。在足月儿中未观察到性别差异，而在两个年龄组中，男性晚期早产儿的 MDI 均低于同龄女性。
当校正早产儿的年龄时，晚期早产儿在 12 个月和 18 个月时的 MDI 评分与足月儿相似。相比之下，当使用实际年龄时，有相当数量的婴儿的 MDI 较低。由于在学龄期晚期早产儿中报告了认知异常，我们的研究结果提出了一个问题，即使用未经年龄校正的评分是否可以早期识别出在学龄期有认知困难的婴儿。
