表皮生长因子 61A>G 遗传多态性与癌症风险：荟萃分析。
Genetic polymorphism of epidermal growth factor 61A>G and cancer risk: a meta-analysis.
机构信息
Department of Internal Medicine, the Second Hospital of Anhui Medical University, 678 Furong Road, Hefei 230601, China.
出版信息
Cancer Epidemiol. 2010 Apr;34(2):150-6. doi: 10.1016/j.canep.2010.02.004. Epub 2010 Mar 5.
BACKGROUND
Numerous studies have investigated the risk of cancer associated with the polymorphism of epidermal growth factor (EGF) 61A>G, but the results have been inconsistent. We performed this meta-analysis to drive a more precise estimation of association between this polymorphism and risk of cancer.
METHODS
Electronic searches of PubMed and EMBASE were conducted to select studies. Case-control studies containing available genotype frequencies of EGF 61A>G were chose, and Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association.
RESULTS
23 case-control studies including 5578 cases and 7306 controls were identified. This meta-analysis showed significant effect of EGF 61A>G on cancer risk (GG vs. AA: OR=1.34, 95%CI=1.05-1.72; GG vs. GA+AA: OR=1.23, 95%CI=1.03-1.47; GG+GA vs. AA: OR=1.18, 95%CI=1.02-1.38). In subgroup analysis, significant increased risk was found in gastric cancer and glioma in additive model (OR=1.54, 95%CI=1.13-2.12; OR=1.69, 95%CI=1.21-2.37) and in recessive model (OR=1.29, 95%CI=1.10-1.52; OR=1.54, 95%CI=1.16-2.04).
CONCLUSION
This meta-analysis suggested that the EGF 61G allele is a risk factor of cancer, especially for gastric cancer and glioma.
背景
许多研究已经调查了与表皮生长因子 (EGF) 61A>G 多态性相关的癌症风险，但结果不一致。我们进行了这项荟萃分析，以更准确地估计这种多态性与癌症风险之间的关联。
方法
电子检索 PubMed 和 EMBASE 以选择研究。选择包含 EGF 61A>G 可用基因型频率的病例对照研究，并使用优势比 (OR) 和 95%置信区间 (CI) 来评估这种关联的强度。
结果
共纳入 23 项病例对照研究，包括 5578 例病例和 7306 例对照。这项荟萃分析显示 EGF 61A>G 对癌症风险有显著影响（GG 与 AA：OR=1.34，95%CI=1.05-1.72；GG 与 GA+AA：OR=1.23，95%CI=1.03-1.47；GG+GA 与 AA：OR=1.18，95%CI=1.02-1.38）。在亚组分析中，在加性模型中发现胃癌和神经胶质瘤的风险显著增加（OR=1.54，95%CI=1.13-2.12；OR=1.69，95%CI=1.21-2.37）和隐性模型（OR=1.29，95%CI=1.10-1.52；OR=1.54，95%CI=1.16-2.04）。
结论
这项荟萃分析表明，EGF 61G 等位基因是癌症的危险因素，特别是胃癌和神经胶质瘤。
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