耐万古霉素敏感金黄色葡萄球菌（MSSA）菌血症持续存在与一株利奈唑胺“耐受”菌株相关。

Persistent methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia due to a linezolid "tolerant" strain.

机构信息

Divisions of Infectious Disease, General Internal Medicine, and Cardiology, Winthrop-University Hospital, Mineola, New York 11501, USA.

出版信息

Heart Lung. 2010 Mar-Apr;39(2):173-5. doi: 10.1016/j.hrtlng.2009.06.005. Epub 2009 Sep 3.

DOI:10.1016/j.hrtlng.2009.06.005

PMID:20207279

Abstract

Antibiotic "tolerance" is a rare cause of antibiotic failure. Antibiotic "tolerance" is defined as an minimal bactericidal concentration (MBC) 32x the minimal inhibitory concentration (MIC) of the isolate. Although susceptibility testing based on the MIC suggests susceptibility of "tolerant" strains, bactericidal concentrations are often beyond achievable serum levels and therapeutic failure may result. We present a case of persistent methicillin-sensitive S. aureus (MSSA) bacteremia due to a linezolid "tolerant" strain unresponsive to daptomycin therapy. We believe this is the first report of persistent MSSA bacteremia due to a linezolid "tolerant" strain.

摘要

抗生素“耐药性”是导致抗生素治疗失败的罕见原因。抗生素“耐药性”被定义为分离株的最小杀菌浓度（MBC）是最小抑菌浓度（MIC）的 32 倍。尽管基于 MIC 的药敏试验提示“耐药”菌株具有敏感性，但杀菌浓度通常超出可达到的血清水平，从而可能导致治疗失败。我们报告了一例由于利奈唑胺“耐药”菌株引起的持续耐甲氧西林金黄色葡萄球菌（MSSA）菌血症，该菌株对达托霉素治疗无反应。我们认为这是首例由于利奈唑胺“耐药”菌株引起的持续 MSSA 菌血症的报告。