氧代苦马豆素 A-F，来自苦马豆属（豆科）植物弯刺黄花根的 N-苯甲酰吲哚类似物。

Oxytrofalcatins A-F, N-benzoylindole analogues from the roots of Oxytropis falcata (Leguminosae).

机构信息

Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, People's Republic of China.

出版信息

Phytochemistry. 2010 Jun;71(8-9):1002-6. doi: 10.1016/j.phytochem.2010.02.010. Epub 2010 Mar 6.

DOI:10.1016/j.phytochem.2010.02.010

PMID:20207380

Abstract

Indole alkaloids, oxytrofalcatins A-F (1-6), together with five other known alkaloids (7-11), were isolated from the roots of Oxytropis falcata. Their structures were elucidated by comprehensive spectroscopic analyses, including using 1D and 2D NMR spectroscopy and mass spectrometry. This is the first report of N-benzoylindoles from a natural source. Compounds 1-6 lacked significant cytotoxicity against SGC-7901 and HL-60 tumor cell lines.

摘要

吲哚生物碱、氧托福定 A-F（1-6）与另外五种已知生物碱（7-11）从苦马豆属植物中分离得到。通过全面的光谱分析，包括使用 1D 和 2D NMR 光谱和质谱，确定了它们的结构。这是首次从天然来源中分离出 N-苯甲酰基吲哚。化合物 1-6 对 SGC-7901 和 HL-60 肿瘤细胞系没有显著的细胞毒性。