Gobbetti A, Zerani M, Botte V
Department of Cellular Biology, University of Camerino, Italy.
Prostaglandins. 1991 Jan;41(1):67-74. doi: 10.1016/0090-6980(91)90106-p.
Plasma patterns of prostaglandin F2 alpha (PGF2 alpha) and sex hormones (progesterone, androgens and 17 beta-estradiol) have been studied in the male crested newt, Triturus carnifex (Laur.), during the sexual cycle. The effects of exogenous PGF2 alpha on sex steroids have also been observed. In addition, effects of one week's captivity are reported. The patterns of plasma sex hormones, during the annual cycle, are consistent with the results previously reported for the same newt species. PGF2 alpha plasma level peaks in April, is low in summer, and progressively increases during autumn to peak again in December. The April PGF2 alpha peak coincides with a plasma estradiol increase and with an androgens drop. In April-collected newts, moreover, PGF2 alpha treatment induces a significant estradiol increase. These findings lead us to suppose that at the end of the breeding season (April) a PGF2 alpha-dependent estradiol synthesis occurs which could be implied in reproductive period termination. In several vertebrates, including some amphibian species, in fact, chronic administration of estradiol results in a strong inhibition of testicular endocrine tissue activity. The putative role of PGF2 alpha-dependent estradiol production in the gonadal regulation in amphibia living in temperate zones is discussed. The autumn PGF2 alpha increase has been tentatively related to the recovery gonadal processes and secondary sexual character development.
在雄性有冠蝾螈（Triturus carnifex，Laur.）的性周期中，对前列腺素F2α（PGF2α）和性激素（孕酮、雄激素和17β-雌二醇）的血浆模式进行了研究。还观察了外源性PGF2α对性类固醇的影响。此外，报告了一周圈养的影响。在年度周期中，血浆性激素模式与先前报道的同一蝾螈物种的结果一致。PGF2α血浆水平在4月达到峰值，夏季较低，秋季逐渐升高，12月再次达到峰值。4月的PGF2α峰值与血浆雌二醇增加和雄激素下降同时出现。此外，在4月采集的蝾螈中，PGF2α处理会导致显著的雌二醇增加。这些发现使我们推测，在繁殖季节结束时（4月）会发生依赖PGF2α的雌二醇合成，这可能与生殖期的终止有关。事实上，在包括一些两栖动物物种在内的几种脊椎动物中，长期施用雌二醇会强烈抑制睾丸内分泌组织的活动。讨论了依赖PGF2α的雌二醇产生在温带两栖动物性腺调节中的假定作用。秋季PGF2α的增加初步与性腺恢复过程和第二性征发育有关。
