Filariasis Research Centre, University of Yaounde I, Yaounde, Cameroon.
Am J Trop Med Hyg. 2010 Mar;82(3):379-85. doi: 10.4269/ajtmh.2010.09-0573.
Onchocerciasis control is currently based on mass ivermectin treatment. Unfortunately, this drug can induce serious adverse events (SAEs) in persons with high levels of Loa loa microfilaremia (> 30,000 microfilaria/mL). A means of preventing SAEs would be to treat at risk populations with a drug that would progressively reduce the microfilarial loads before administering ivermectin. Antimalarial drugs are a potential solution because they have shown some activity against various filarial species. A controlled trial was conducted to assess the effect of standard doses of quinine, chloroquine, amodiaquine, and artesunate on L. loa microfilaremia. Ninety-eight patients were randomly allocated into five groups (one for each drug and a control group) after stratification on microfilarial load. Loa loa microfilaremia was monitored on days 0, 3, 7, 15, 30, 60, and 90. No significant change in the loads was recorded in any of the treatment groups. A comprehensive review of the effects of antimalarial drugs against filariae is also provided.
盘尾丝虫病的控制目前基于大规模伊维菌素治疗。不幸的是,这种药物会在高水平的罗阿罗阿微丝蚴血症(> 30,000 微丝蚴/毫升)患者中引起严重不良事件(SAEs)。预防 SAE 的一种方法是用一种药物治疗高危人群,该药物在给予伊维菌素之前会逐渐降低微丝蚴负荷。抗疟药物是一种潜在的解决方案,因为它们对各种丝虫物种表现出一定的活性。进行了一项对照试验,以评估标准剂量的奎宁、氯喹、阿莫地喹和青蒿琥酯对罗阿罗阿微丝蚴血症的影响。98 名患者在微丝蚴负荷分层后随机分配到五个组(每组一种药物和一个对照组)。在第 0、3、7、15、30、60 和 90 天监测罗阿罗阿微丝蚴血症。在任何治疗组中,负荷均未记录到明显变化。还提供了对抗丝虫病药物对抗丝虫病的综合影响的综述。