一项评估奎宁、氯喹、阿莫地喹和青蒿琥酯对罗阿罗阿微丝蚴血症影响的对照试验。
A controlled trial to assess the effect of quinine, chloroquine, amodiaquine, and artesunate on Loa loa microfilaremia.
机构信息
Filariasis Research Centre, University of Yaounde I, Yaounde, Cameroon.
出版信息
Am J Trop Med Hyg. 2010 Mar;82(3):379-85. doi: 10.4269/ajtmh.2010.09-0573.
Abstract
Onchocerciasis control is currently based on mass ivermectin treatment. Unfortunately, this drug can induce serious adverse events (SAEs) in persons with high levels of Loa loa microfilaremia (> 30,000 microfilaria/mL). A means of preventing SAEs would be to treat at risk populations with a drug that would progressively reduce the microfilarial loads before administering ivermectin. Antimalarial drugs are a potential solution because they have shown some activity against various filarial species. A controlled trial was conducted to assess the effect of standard doses of quinine, chloroquine, amodiaquine, and artesunate on L. loa microfilaremia. Ninety-eight patients were randomly allocated into five groups (one for each drug and a control group) after stratification on microfilarial load. Loa loa microfilaremia was monitored on days 0, 3, 7, 15, 30, 60, and 90. No significant change in the loads was recorded in any of the treatment groups. A comprehensive review of the effects of antimalarial drugs against filariae is also provided.
摘要
盘尾丝虫病的控制目前基于大规模伊维菌素治疗。不幸的是，这种药物会在高水平的罗阿罗阿微丝蚴血症（> 30,000 微丝蚴/毫升）患者中引起严重不良事件（SAEs）。预防 SAE 的一种方法是用一种药物治疗高危人群，该药物在给予伊维菌素之前会逐渐降低微丝蚴负荷。抗疟药物是一种潜在的解决方案，因为它们对各种丝虫物种表现出一定的活性。进行了一项对照试验，以评估标准剂量的奎宁、氯喹、阿莫地喹和青蒿琥酯对罗阿罗阿微丝蚴血症的影响。98 名患者在微丝蚴负荷分层后随机分配到五个组（每组一种药物和一个对照组）。在第 0、3、7、15、30、60 和 90 天监测罗阿罗阿微丝蚴血症。在任何治疗组中，负荷均未记录到明显变化。还提供了对抗丝虫病药物对抗丝虫病的综合影响的综述。
相似文献
1
A controlled trial to assess the effect of quinine, chloroquine, amodiaquine, and artesunate on Loa loa microfilaremia.一项评估奎宁、氯喹、阿莫地喹和青蒿琥酯对罗阿罗阿微丝蚴血症影响的对照试验。
Am J Trop Med Hyg. 2010 Mar;82(3):379-85. doi: 10.4269/ajtmh.2010.09-0573.
2
Loa loa microfilarial periodicity in ivermectin-treated patients: comparison between those developing and those free of serious adverse events.伊维菌素治疗患者中罗阿罗阿微丝蚴的周期性：发生和无严重不良事件者的比较。
Am J Trop Med Hyg. 2009 Dec;81(6):1056-61. doi: 10.4269/ajtmh.2009.09-0356.
3
Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection.在罗阿丝虫感染流行地区用伊维菌素大规模治疗盘尾丝虫病后的严重反应。
Lancet. 1997 Jul 5;350(9070):18-22. doi: 10.1016/S0140-6736(96)11094-1.
4
Ocular findings after ivermectin treatment of patients with high Loa loa microfilaremia.用伊维菌素治疗高盘尾丝虫微丝蚴血症患者后的眼部表现。
Ophthalmic Epidemiol. 2000 Mar;7(1):27-39.
5
Randomized, controlled, double-blind trial with ivermectin on Loa loa microfilaraemia: efficacy of a low dose (approximately 25 microg/kg) versus current standard dose (150 microg/kg).伊维菌素治疗罗阿丝虫微丝蚴血症的随机对照双盲试验：低剂量（约25微克/千克）与现行标准剂量（150微克/千克）的疗效比较
Trans R Soc Trop Med Hyg. 2007 Aug;101(8):777-85. doi: 10.1016/j.trstmh.2007.03.018. Epub 2007 May 24.
6
7
A novel antigen biomarker for detection of high-level of Loa loa microfilaremia.一种用于检测高水平罗阿罗阿微丝蚴的新型抗原生物标志物。
PLoS Negl Trop Dis. 2024 Sep 3;18(9):e0012461. doi: 10.1371/journal.pntd.0012461. eCollection 2024 Sep.
8
Absence of Microfilaremia among Newly Arrived Congolese Refugees in Texas.德克萨斯州新抵达的刚果难民中无微丝蚴血症
Am J Trop Med Hyg. 2017 Dec;97(6):1833-1835. doi: 10.4269/ajtmh.17-0337. Epub 2017 Aug 31.
9
Heterogeneity in the in vitro susceptibility of Loa loa microfilariae to drugs commonly used in parasitological infections.罗阿丝虫微丝蚴对常用于寄生虫感染的药物的体外敏感性的异质性。
Parasit Vectors. 2018 Apr 4;11(1):223. doi: 10.1186/s13071-018-2799-3.
10
[Secondary effects of the treatment of hypermicrofilaremic loiasis using ivermectin].[使用伊维菌素治疗高微丝蚴血症盘尾丝虫病的继发效应]
Bull Soc Pathol Exot. 1995;88(3):105-12.
引用本文的文献
1
Safety and efficacy of 3- and 5-day regimens of levamisole in loiasis: a randomized, placebo-controlled, double-blind clinical trial.左旋咪唑3天和5天疗程治疗罗阿丝虫病的安全性和有效性：一项随机、安慰剂对照、双盲临床试验
Nat Commun. 2025 Jul 4;16(1):6191. doi: 10.1038/s41467-025-61479-6.
2
Advances in preclinical platforms of for filarial neglected tropical disease drug and diagnostics research.用于丝虫类被忽视热带病药物和诊断研究的临床前平台的进展。
Front Trop Dis. 2021 Nov 8;2. doi: 10.3389/fitd.2021.778724.
3
Systematic review and meta-analysis of the safety of chloroquine and hydroxychloroquine from randomized controlled trials on malarial and non-malarial conditions.系统评价和荟萃分析随机对照试验中氯喹和羟氯喹在疟疾和非疟疾情况下的安全性。
Syst Rev. 2021 Nov 4;10(1):294. doi: 10.1186/s13643-021-01835-x.
4
Safety and Efficacy of Levamisole in Loiasis: A Randomized, Placebo-controlled, Double-blind Clinical Trial.洛美索在罗阿丝虫病中的安全性和疗效：一项随机、安慰剂对照、双盲临床试验。
Clin Infect Dis. 2022 Aug 24;75(1):19-27. doi: 10.1093/cid/ciab906.
5
Case Report: Probable Case of Spontaneous Encephalopathy Due to Loiasis and Dramatic Reduction of Microfilariaemia with Prolonged Repeated Courses of Albendazole.病例报告：可能由罗阿丝虫病引起的自发性脑病，以及反复多次使用阿苯达唑后微丝蚴血症显著降低。
Am J Trop Med Hyg. 2018 Jul;99(1):112-115. doi: 10.4269/ajtmh.17-0664. Epub 2018 May 3.
6
Evaluation of in vitro culture systems for the maintenance of microfilariae and infective larvae of Loa loa.评价用于维持罗阿罗阿微丝蚴和感染性幼虫的体外培养系统。
Parasit Vectors. 2018 May 2;11(1):275. doi: 10.1186/s13071-018-2852-2.
7
Heterogeneity in the in vitro susceptibility of Loa loa microfilariae to drugs commonly used in parasitological infections.罗阿丝虫微丝蚴对常用于寄生虫感染的药物的体外敏感性的异质性。
Parasit Vectors. 2018 Apr 4;11(1):223. doi: 10.1186/s13071-018-2799-3.
8
Operationalization of the test and not treat strategy to accelerate the elimination of onchocerciasis and lymphatic filariasis in Central Africa.实施“检测与不治疗”策略以加速中非盘尾丝虫病和淋巴丝虫病的消除
Int Health. 2018 Mar 1;10(suppl_1):i49-i53. doi: 10.1093/inthealth/ihx051.
9
Repurposing drugs for the treatment and control of helminth infections.药物重新利用以治疗和控制蠕虫感染。
Int J Parasitol Drugs Drug Resist. 2014 Jul 30;4(3):185-200. doi: 10.1016/j.ijpddr.2014.07.002. eCollection 2014 Dec.
本文引用的文献
1
Loa loa microfilarial periodicity in ivermectin-treated patients: comparison between those developing and those free of serious adverse events.伊维菌素治疗患者中罗阿罗阿微丝蚴的周期性：发生和无严重不良事件者的比较。
Am J Trop Med Hyg. 2009 Dec;81(6):1056-61. doi: 10.4269/ajtmh.2009.09-0356.
2
Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols.抗疟喹啉甲醇的杀血吸虫作用机制之一是抑制亚铁血红素形成。
PLoS Negl Trop Dis. 2009 Jul 14;3(7):e477. doi: 10.1371/journal.pntd.0000477.
3
Effect of single-dose oral mefloquine on the morphology of adult Schistosoma japonicum in mice.单剂量口服甲氟喹对小鼠体内日本血吸虫成虫形态的影响。
Parasitol Res. 2009 Sep;105(3):853-61. doi: 10.1007/s00436-009-1471-4. Epub 2009 May 21.
4
Histopathological changes in adult Schistosoma japonicum harbored in mice treated with a single dose of mefloquine.单剂量甲氟喹治疗小鼠体内日本血吸虫成虫的组织病理学变化
Parasitol Res. 2009 Jun;104(6):1407-16. doi: 10.1007/s00436-009-1341-0. Epub 2009 Feb 17.
5
Mefloquine--an aminoalcohol with promising antischistosomal properties in mice.甲氟喹——一种在小白鼠体内具有抗血吸虫特性的氨醇。
PLoS Negl Trop Dis. 2009;3(1):e350. doi: 10.1371/journal.pntd.0000350. Epub 2009 Jan 6.
6
Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum.喹啉类抗疟药对恶性疟原虫内吞作用的差异效应。
Antimicrob Agents Chemother. 2008 May;52(5):1840-2. doi: 10.1128/AAC.01478-07. Epub 2008 Mar 3.
7
Artemisinins and synthetic trioxolanes in the treatment of helminth infections.青蒿素和合成三氧杂环已烷在治疗蠕虫感染中的应用。
Curr Opin Infect Dis. 2007 Dec;20(6):605-12. doi: 10.1097/QCO.0b013e3282f19ec4.
8
Pumping iron: a potential target for novel therapeutics against schistosomes.锻炼肌肉：针对血吸虫病的新型疗法的潜在靶点
Trends Parasitol. 2007 Dec;23(12):583-8. doi: 10.1016/j.pt.2007.08.018. Epub 2007 Oct 24.
9
Randomized, controlled, double-blind trial with ivermectin on Loa loa microfilaraemia: efficacy of a low dose (approximately 25 microg/kg) versus current standard dose (150 microg/kg).伊维菌素治疗罗阿丝虫微丝蚴血症的随机对照双盲试验：低剂量（约25微克/千克）与现行标准剂量（150微克/千克）的疗效比较
Trans R Soc Trop Med Hyg. 2007 Aug;101(8):777-85. doi: 10.1016/j.trstmh.2007.03.018. Epub 2007 May 24.
10
What are the mechanisms associated with post-ivermectin serious adverse events?与伊维菌素治疗后严重不良事件相关的机制是什么？
Trends Parasitol. 2006 Jun;22(6):244-6. doi: 10.1016/j.pt.2006.04.006. Epub 2006 Apr 24.
Zotero 插件