喹啉类抗疟药对恶性疟原虫内吞作用的差异效应。
Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum.
作者信息
Roberts Lindi, Egan Timothy J, Joiner Keith A, Hoppe Heinrich C
机构信息
Division of Pharmacology, University of Cape Town Medical School, Observatory 7925, Cape Town, South Africa.
出版信息
Antimicrob Agents Chemother. 2008 May;52(5):1840-2. doi: 10.1128/AAC.01478-07. Epub 2008 Mar 3.
Abstract
The effects of quinoline antimalarials on endocytosis by Plasmodium falciparum was investigated by measuring parasite hemoglobin levels, peroxidase uptake, and transport vesicle content. Mefloquine, quinine, and halofantrine inhibited endocytosis, and chloroquine inhibited vesicle trafficking, while amodiaquine shared both effects. Protease inhibitors moderated hemoglobin perturbations, suggesting a common role for heme binding.
摘要
通过测量疟原虫血红蛋白水平、过氧化物酶摄取和运输囊泡含量，研究了喹啉类抗疟药对恶性疟原虫内吞作用的影响。甲氟喹、奎宁和卤泛群抑制内吞作用，氯喹抑制囊泡运输，而阿莫地喹兼具这两种作用。蛋白酶抑制剂减轻了血红蛋白的扰动，表明血红素结合具有共同作用。
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