牛初乳抗人轮状病毒感染功效的体外和体内评估
In vitro and in vivo evaluation of the efficacy of bovine colostrum against human rotavirus infection.
作者信息
Inagaki Mizuho, Yamamoto Mayumi, Uchida Kenji, Yamaguchi Hiroshi, Kawasaki Mihoko, Yamashita Kousaku, Yabe Tomio, Kanamaru Yoshihiro
机构信息
United Graduate School of Agricultural Science, Gifu University, Yanagido, Gifu, Japan.
出版信息
Biosci Biotechnol Biochem. 2010;74(3):680-2. doi: 10.1271/bbb.90862. Epub 2010 Mar 7.
We found that skimmed and concentrated bovine late colostrum (SCBLC) obtained from normal cows at 6-7 d after parturition exhibited high potency in inhibiting replication of human rotavirus (HRV) in vitro. Furthermore, prophylactic oral administration of SCBLC once before inoculation of HRV prevented the development of diarrhea in suckling mice in vivo. SCBLC from normal cows might be useful in the prevention of HRV-induced severe gastroenteritis in immunocompromised hosts.
我们发现，从正常母牛分娩后6 - 7天获取的脱脂浓缩牛晚期初乳（SCBLC）在体外对人轮状病毒（HRV）的复制具有高效抑制作用。此外，在接种HRV前预防性口服SCBLC可预防乳鼠体内腹泻的发生。正常母牛的SCBLC可能有助于预防免疫功能低下宿主中由HRV引起的严重肠胃炎。
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