Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
J Epidemiol. 2010;20(3):225-30. doi: 10.2188/jea.je20090051. Epub 2010 Mar 6.
Many studies have reported an association between physical activity and cardiovascular disease (CVD); however, the effect of physical activity remains controversial. Few such studies have been conducted in Japan. Therefore, we examined the relationship between physical activity and death from CVD using prospective data from a Japanese population.
From a prospective cohort study that comprised 12 490 participants, data from 9810 were analyzed. From April 1992 through July 1995, a baseline survey was conducted in 12 communities in Japan. The participants were followed up until December 2005. Physical activity was assessed using the physical activity index (PAI). PAI scores were grouped in quartiles: Q1 was the lowest PAI quartile and Q4 was the highest. Hazard ratios (HRs) for death from CVD, stroke, and myocardial infarction (MI) were calculated for all PAI quartiles.
The mean follow-up period was 11.9 years, during which time 194 participants died of CVD. With Q1 as the reference, the HRs for death from CVD in Q2, Q3, and Q4, were 0.62 (95% confidence interval, 0.40-0.98), 0.53 (0.31-0.88), and 0.40 (0.22-0.73), respectively, in men, and 0.71 (0.38-1.32), 0.52 (0.26-1.04), and 0.48 (0.22-1.05), respectively, in women. The HRs for death from CVD subtypes were similar but not statistically significant.
Among a Japanese population, physical activity was associated with a decreased risk of death from CVD. However, more evidence is needed to elucidate the relationships between physical activity and CVD subtypes.
许多研究报告了身体活动与心血管疾病（CVD）之间的关联；然而，身体活动的效果仍存在争议。在日本进行的此类研究很少。因此，我们使用日本人群的前瞻性数据来检查身体活动与 CVD 死亡之间的关系。
从一项包含 12490 名参与者的前瞻性队列研究中，分析了 9810 名参与者的数据。1992 年 4 月至 1995 年 7 月，在日本的 12 个社区进行了基线调查。参与者随访至 2005 年 12 月。身体活动使用体力活动指数（PAI）进行评估。PAI 评分分为四组：Q1 是最低 PAI 四分位数，Q4 是最高 PAI 四分位数。计算了所有 PAI 四分位数的 CVD、中风和心肌梗死（MI）死亡的危险比（HR）。
平均随访时间为 11.9 年，在此期间有 194 名参与者死于 CVD。以 Q1 为参考，Q2、Q3 和 Q4 的 CVD 死亡 HR 分别为 0.62（95%置信区间，0.40-0.98）、0.53（0.31-0.88）和 0.40（0.22-0.73），男性；0.71（0.38-1.32）、0.52（0.26-1.04）和 0.48（0.22-1.05），女性。CVD 亚型死亡的 HR 相似，但无统计学意义。
在日本人群中，身体活动与 CVD 死亡风险降低相关。然而，需要更多证据来阐明身体活动与 CVD 亚型之间的关系。
