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1型糖尿病儿童和青少年的严重低血糖症

[Severe hypoglycemia in children and adolescents suffering from type 1 diabetes mellitus].

作者信息

Cosmescu Adriana, Felea Doina, Mătăsaru Silvia

机构信息

Facultatea de Medicină, Disciplina Medicină de Familie, Universitatea de Medicina Si Farmacie "Gr.T. Popa" Iaşi .

出版信息

Rev Med Chir Soc Med Nat Iasi. 2008 Oct-Dec;112(4):955-8.

Abstract

UNLABELLED

Hypoglycemia is the main fear of diabetic children and their parents. Severe hypoglycemia and diabetes ketoacidosis are medical emergencies that concern a patient's life prognosis.

AIM

To determine the rate of occurrence of severe hypoglycemia and identification of the latter's causes.

MATERIAL AND METHOD

The study was carried out on a group of 84 children and adolescents suffering from type 1 diabetes, whom were investigated to determine the rate of occurrence of severe hypoglycemia episodes in the last 12 months, to identify their risk factors and to try to establish a relation between the onset of hypoglycemia and certain parameters like age, duration of disease, insulin therapy, metabolic control.

RESULTS

23 of the 84 patients reported at least one severe hypoglycemia in the last 12 months. 47% of the cases of hypoglycemia were caused by the patient's failure to observe the meal timetable, which led to delays in the carbohydrates intake, 19% were due to a high physical effort and 14% by excessive insulin administration. Most of the patients with severe hypoglycemia, that is 20 if 23, were on a multiple insulin injection treatment. As concerns the blood sugar balance, the mean Hb A1c values were between 6.4% and 9.1%, the severe hypoglycemia episodes occurred both in patients with very good metabolic control and in those with poor blood sugar balance.

CONCLUSIONS

Severe hypoglycemia occurred in 27.3% of the children and adolescents suffering from type 1 diabetes, the most frequent cause revealed by this study being the delay in the carbohydrates intake. The prevention of this acute metabolic complication by a continuous medical education of diabetic patients is essential.

摘要

未标注

低血糖是糖尿病患儿及其家长主要担心的问题。严重低血糖和糖尿病酮症酸中毒是关乎患者生命预后的医疗急症。

目的

确定严重低血糖的发生率并找出其原因。

材料与方法

对一组84名1型糖尿病儿童和青少年进行研究,调查他们在过去12个月中严重低血糖发作的发生率,确定其危险因素,并试图建立低血糖发作与某些参数(如年龄、病程、胰岛素治疗、代谢控制)之间的关系。

结果

84名患者中有23名报告在过去12个月中至少发生过一次严重低血糖。47%的低血糖病例是由于患者未遵守用餐时间表,导致碳水化合物摄入延迟,19%是由于高强度体力活动,14%是由于胰岛素过量注射。大多数严重低血糖患者,即23名中的20名,采用多次胰岛素注射治疗。关于血糖平衡,平均糖化血红蛋白(Hb A1c)值在6.4%至9.1%之间,严重低血糖发作在代谢控制非常好的患者和血糖平衡差的患者中均有发生。

结论

1型糖尿病儿童和青少年中27.3%发生了严重低血糖,本研究显示最常见的原因是碳水化合物摄入延迟。通过对糖尿病患者进行持续的医学教育来预防这种急性代谢并发症至关重要。

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