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[肺结核或结节病]

[Tuberculosis or sarcoidosis].

作者信息

Pop Monica, Ghigolea Ioana, Mureşan Alina, Râjnoveanu Ruxandra, Dadu Ramona, Pui Aurora

机构信息

Disciplina de Pneumologie, Facultatea de Medicină, Universitatea de Medicină si Farmacie I. Haţieganu Cluj Napoca.

出版信息

Rev Med Chir Soc Med Nat Iasi. 2008 Oct-Dec;112(4):959-64.

Abstract

Tuberculosis and sarcoidosis are two different diseases with different etiology, clinical features and treatment. Both are granulomatous disease, but tuberculosis has a caseating necrosis granuloma as opposed to sarcoidosis witch present noncaseating epithelioid cell granuloma. If chest radiography shows hilar lymphadenopathy and hystopatological features reveal no caseating necrosis granuloma the differential diagnosis might be difficult. This is a case of abdominal adenopathy in a 39-years-old male, with a past medical history significant for pulmonary tuberculosis. The patient was admitted to the hospital for mild epigastric pain and weight loss (14 kg for the last year). The abdominal ultrasound and CT scan revealed retroperitoneal lymph node enlargement. Chest X-ray revealed bilateral hilar adenopathy and mediastinal adenopathy. After various differential diagnoses were considered, a diagnostic laparoscopy and a lymph node biopsy were performed. The pathology report showed chronic necrotizing granuloma. The case was interpreted as lymph node sarcoidosis and treated with corticosteroids (Prednisone). After one month of treatment the patient complained of dry cough, night sweats, fatigability, decreased appetite and weight loss. Pathological findings of chest radiography and CT scan with iv contrast (left upper lobe infiltrate, right lower lobe ill-defined mass, multiple small nodular opacities scattered throughout both lung fields, bilateral hilar and mediastinal adenopathy, lymph nodes near celiac trunk were enlarged) and positive acid-fast bacilli of sputum smears point to the real diagnosis of pulmonary tuberculosis and abdominal lymph nodes tuberculosis. The patient was started on a daily treatment with Isoniazid, Pyrasinamide, Ethambutol, Streptomycine, Cyprofloxacine, Cicloserine and Protionamide (he was allergic to Rifampin). Five months later the clinical and radiological findings were almost normal and the sputum smear for acid-fast bacili was negative.

摘要

结核病和结节病是两种不同的疾病,病因、临床特征和治疗方法各异。两者均为肉芽肿性疾病,但结核病有干酪样坏死性肉芽肿,而结节病则表现为非干酪样上皮样细胞肉芽肿。如果胸部X线检查显示肺门淋巴结肿大,且组织病理学特征未发现干酪样坏死性肉芽肿,则鉴别诊断可能会很困难。这是一例39岁男性腹部淋巴结肿大的病例,既往有肺结核病史。患者因轻度上腹部疼痛和体重减轻(过去一年减轻14公斤)入院。腹部超声和CT扫描显示腹膜后淋巴结肿大。胸部X线检查显示双侧肺门淋巴结肿大和纵隔淋巴结肿大。在考虑了各种鉴别诊断后,进行了诊断性腹腔镜检查和淋巴结活检。病理报告显示为慢性坏死性肉芽肿。该病例被诊断为淋巴结结节病,并接受了皮质类固醇(泼尼松)治疗。治疗一个月后,患者出现干咳、盗汗、疲劳、食欲减退和体重减轻。胸部X线检查和CT增强扫描的病理结果(左上叶浸润、右下叶边界不清的肿块、双肺野散在多个小结节状阴影、双侧肺门和纵隔淋巴结肿大、腹腔干附近淋巴结肿大)以及痰涂片抗酸杆菌阳性提示真正的诊断为肺结核和腹部淋巴结结核。患者开始每日服用异烟肼、吡嗪酰胺、乙胺丁醇、链霉素、环丙沙星、环丝氨酸和丙硫异烟胺(他对利福平过敏)。五个月后,临床和影像学检查结果几乎恢复正常,痰涂片抗酸杆菌阴性。

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