Ben Slama Fethi, Boujmil Amira, Dekhil Imen, Trimeche Abdelmajid, Gaouar Chakib, Ben Rayana Mohamed Chiheb, Achour Noureddine, Zouari Béchir, Achour Ahmed, Bel Hadj Omrane
Institut National de la Santé Publique.
Tunis Med. 2009 Nov;87(11):726-30.
At the obese ones, there is an imbalance between the free defenses antioxydants and radicals from where the installation of an oxydative stress, responsible for the development of non-insulin-dependent diabetes.
Our objectives was to evaluate the levels of vitamins A, E and of leptin, to search the link witch could exist between vitamins and leptin.
We proportioned the rates in vitamins A, E and in leptine at 30 obese subjects diabetic of type 2 including 12 men and 18 women of average age (50.93 +/- 6.13) years not carrying pathologies other than the diabetes and obesity compared to 30 witnesses who theirs are paired according to the age and the sex..
Our results chows that levels of antioxidants did not differ between the two groups but we find a non significant decrease in vitamin E/(TC +TG) ratio (1.86 +/- 0.38 vs. 2.11 +/- 0.74 ; p = 0.08) and significant increase of vitamin A level in women obese with non-insulin-diabetes mellitus compared with control group of women (0.69 +/- 0.16 vs. 0.55 +/- 0.15 ; p = 0.01). Moreover a negative and significative correlation between vitamin E and leptin (r = 0.452 ; p = 0.01), and a negative and no significative correlation between vitamin A and leptin (2 = - 0.221; p > 0.05) were observed.
The rate of vitamin A, is different for each sex with share. The vitamin E could have a negative control on the secretion of the leptin.
在肥胖人群中，抗氧化剂的自由防御与自由基之间存在失衡，由此引发氧化应激，这是导致非胰岛素依赖型糖尿病的原因。
我们的目标是评估维生素A、E和瘦素的水平，以探寻维生素与瘦素之间可能存在的联系。
我们测定了30名2型糖尿病肥胖受试者（包括12名男性和18名女性，平均年龄为(50.93±6.13)岁，除糖尿病和肥胖外无其他疾病）的维生素A、E和瘦素水平，并与30名根据年龄和性别配对的对照组进行比较。
我们的结果显示，两组之间抗氧化剂水平没有差异，但我们发现维生素E/(总胆固醇+甘油三酯)比值有不显著下降（1.86±0.38 vs. 2.11±0.74；p = 0.08），与女性对照组相比，非胰岛素依赖型糖尿病肥胖女性的维生素A水平显著升高（0.69±0.16 vs. 0.55±0.15；p = 0.01）。此外，观察到维生素E与瘦素之间存在负相关且具有显著性（r = 0.452；p = 0.01），维生素A与瘦素之间存在负相关但不具有显著性（r = - 0.221；p > 0.05）。
维生素A的水平因性别而异。维生素E可能对瘦素的分泌有负向控制作用。
