Derevianko T I
Urologiia. 2009 Sep-Oct(5):18-21.
Ectopia of the urethral opening (female hypospadia) often causes chronic recurrent cystitis in women because of a retrograde delivery of urogenital infection from the introitus and vagina to the short wide urethra and urinary bladder. Etiologically, cystitis develops due to pathogenic vaginal microflora: Chlamydia trachomatis, Mycoplasma genitalium, Ureaplasma, urealyticum, Gardnerella vaginalis, Candida, E. coli and other gram-negative bacteria. In 64 female patients aged 16-57 years with female hypospadia (FH) the diagnosis was made by O'Donnel-Hirchhorn symptom. Identification of urinary and vaginal microflora was made using polymerase chain reaction. Radical treatment of chronic recurrent cystitis in FH is surgical transposition of the distal urethra and its opening in the typical place with pre- and perioperative anti-inflammatory therapy according to the pathogen or with drugs having combined antimycotic and antiprotosoic properties. One of such drugs safocid demonstrates a rapid therapeutic effect in mixed urogenital infections causing chronic recurrent cystitis in women.
尿道外口异位（女性尿道下裂）常导致女性慢性复发性膀胱炎，这是因为泌尿生殖系统感染会从阴道口和阴道逆行至短而宽的尿道及膀胱。从病因学角度来看，膀胱炎是由致病性阴道微生物群引发的：沙眼衣原体、生殖支原体、解脲脲原体、阴道加德纳菌、念珠菌、大肠杆菌及其他革兰氏阴性菌。在64例年龄在16至57岁的患有女性尿道下裂（FH）的女性患者中，通过奥唐纳 - 赫希霍恩症状做出诊断。使用聚合酶链反应对尿液和阴道微生物群进行鉴定。对于FH患者慢性复发性膀胱炎的根治性治疗是将尿道远端进行手术移位并将其开口置于典型位置，同时根据病原体进行术前和围手术期抗炎治疗，或使用具有抗真菌和抗原生动物联合特性的药物。其中一种药物萨福西在导致女性慢性复发性膀胱炎的混合泌尿生殖系统感染中显示出快速的治疗效果。
