Wang Yiwei, Liang Rixin, Yang Weipeng, Wang Yanli, Weng Xiaogang, Yang Qing, Wang Lan, Zhu Xiaoxin
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2009 Nov;34(21):2701-3.
Since pang set up the perfused rat intestine-liver preparation and applied it to study the disposition of enalapril, this model has been widely considered to have the particularly advantage in studying the absorption, metabolism and first-pass effect. Now the methods and applications are to be reviewed and the perspective is to be discussed.
自从庞建立了灌注大鼠肠-肝制备模型并将其应用于研究依那普利的处置以来，该模型在研究吸收、代谢和首过效应方面一直被广泛认为具有独特优势。现将其方法和应用进行综述并探讨前景。
