川芎嗪对大鼠佐剂性关节炎血管内皮生长因子表达及病情发展的影响
[Relationship of tetramethylpyrazine on expression of vascular endothelial growth factor and development of adjuvant-induced arthritis in rats].
作者信息
Ma Qiang, Chen Gang, Zhang Jifen, Feng Binbin, Xu Xiaoyu
机构信息
College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2009 Nov;34(21):2799-802.
OBJECTIVE
To explore the effect of tetramethylpyrazine (TMP) on the expression of vascular endothelial growth factor (VEGF) in the synovium of adjuvant-induced arthritis (AIA) in rats.
METHOD
AIA rats were treated with different doses of TMP. The effects of treatment were monitored by footpad thickness, contents of tumor necrosis factor-alpha (TNF-alpha) in serum, microvessel density (MVD) and the expression of VEGF protein in the synovium.
RESULT
Compared with arthritis model, 100 mg x kg(-1) TMP could remarkably reduce the footpad thickness, contents of TNF-alpha in serum and the expression of VEGF in the synovium.
CONCLUSION
TMP can attenuate the degree of chronic inflammation in AIA rats, and its mechanism might be associated with inhibiting the expression of VEGF.
目的
探讨川芎嗪（TMP）对佐剂性关节炎（AIA）大鼠滑膜中血管内皮生长因子（VEGF）表达的影响。
方法
用不同剂量的TMP治疗AIA大鼠。通过足垫厚度、血清中肿瘤坏死因子-α（TNF-α）含量、微血管密度（MVD）及滑膜中VEGF蛋白表达来监测治疗效果。
结果
与关节炎模型相比，100mg·kg⁻¹的TMP可显著降低足垫厚度、血清中TNF-α含量及滑膜中VEGF的表达。
结论
TMP可减轻AIA大鼠慢性炎症程度，其机制可能与抑制VEGF表达有关。
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