Ren Yong-qiang, Lu Qing, Cao Wei-gang
Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.
Zhonghua Zheng Xing Wai Ke Za Zhi. 2009 Nov;25(6):433-6.
To assess the feasibility of interstitial magnetic resonance lymphangiography (IMRL) with intracutaneous injection of gadobenate dimeglumine--a commercially available, non-ionic, extracellular paramagnetic contrast agent.
We studied 10 patients with lower extremity lymphedema. A mixture of 7.5 ml gadobenate dimeglumine and 0.5 ml 2% lidocaine were evenly subdivided into 8 portions and injected intracutaneously into each web space of both feet. For IMRL, a 3D fast spoiled gradient-recalled echo T1-weighted images with a fat saturation technique (T1 high resolution isotropic volume excitation, THRIVE) was performed.
The beaded appearance of lymphatic vessels extending from the injection site were detected in 11 of 12 lower legs and the best delineation of lymphatic vessels was present at 15-30 minutes after injection. In 6 of 12 affected thighs, lymphatic vessels could be also visualized with the strongest enhancement at 45 minutes.
IMRL is a safe and technically feasible new method which can effectively visualize the pathological lymphatic vessels in lower extremity lymphedema.
评估皮内注射钆贝葡胺（一种市售的非离子细胞外顺磁性造影剂）进行间质磁共振淋巴造影（IMRL）的可行性。
我们研究了10例下肢淋巴水肿患者。将7.5毫升钆贝葡胺和0.5毫升2%利多卡因的混合物均匀分成8份，皮内注射到双脚的每个趾蹼间隙。对于IMRL，采用脂肪饱和技术的三维快速扰相梯度回波T1加权成像（T1高分辨率各向同性容积激发，THRIVE）。
在12条小腿中的11条中检测到从注射部位延伸的淋巴管呈串珠状，注射后15 - 30分钟淋巴管显示最佳。在12条受影响大腿中的6条中，也可在45分钟时观察到淋巴管，此时增强最为明显。
IMRL是一种安全且技术上可行的新方法，可有效显示下肢淋巴水肿中的病理性淋巴管。
