Miyahira Takumi, Teruya Natsuki, Matsuura Fumiaki, Murayama Shigemi, Aka Hiroyuki, Teruya Jun, Hanashiro Naoji, Nishihara Minoru, Okushima Norihiko, Toda Yoshitaka, Kiyuna Masaya
Dept. of Surgery, Heartlife Hospital
Gan To Kagaku Ryoho. 2010 Feb;37(2):331-4.
A 73-year-old man had undergone right hemicolectomy for advanced colon cancer in May 2006, and he concurrently had multiple liver metastases. After the operation, the patient was given chemotherapy with FOLFIRI. A partial response was achieved for twelve months, and then the liver tumors enlarged. Second-line chemotherapy with FOLFOX was delivered. After several months the liver tumors further enlarged and a new pulmonary lesion appeared with an increased serum CEA level. Therefore, chemotherapy with S-1 (120 mg/day) was started, with 2 weeks' administration followed by a one-week drug-free period. Several months later, the liver tumors and tumor makers decreased. S-1 is expected to be an effective agent for the treatment of advanced colon cancer with liver metastases after FOLFIRI and FOLFOX.
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