湿度以及羟丙基纤维素、羟丙基甲基纤维素、山嵛酸甘油酯或硬脂酸镁对盐酸喹那普利在固相中降解动力学的影响。

Influence of humidity and hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate or magnesium stearate on the degradation kinetics of quinapril hydrochloride in solid phase.

作者信息

Stanisz Beata, Paszun Sylwia, Strzyzycka Natalia, Ptaszyński Emil

机构信息

Department of Pharmaceutical Chemistry, Karol Marcinkowski University of Medical Sciences, 60-780 Poznań, 6 Grunwaldzka St., Poland.

出版信息

Acta Pol Pharm. 2010 Jan-Feb;67(1):99-102.

PMID:20210086

Abstract

Catalytic effect of hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate and magnesium stearate in the presence of 50.9% - 76.4% humidity at 318 K on stability of quinapril hydrochloride (QHCl) was examined by HPLC method. The differences in kinetic mechanism of degradation of QHCl were observed. The effect of humidity on QHCl stability in the presence of hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate or magnesium stearate was linear and according to the equation ln k(i) = aRH% + b.

摘要

采用高效液相色谱法研究了羟丙基纤维素、羟丙基甲基纤维素、山嵛酸甘油酯和硬脂酸镁在318K、湿度为50.9%-76.4%条件下对盐酸喹那普利（QHCl）稳定性的催化作用。观察到QHCl降解动力学机制的差异。湿度对在羟丙基纤维素、羟丙基甲基纤维素、山嵛酸甘油酯或硬脂酸镁存在下的QHCl稳定性的影响呈线性关系，符合方程ln k(i) = aRH% + b。