盐酸喹那普利——非晶态和晶态混合物（QHCl - AC）在固相中稳定性。
The stability of quinapril hydrochloride--a mixture of amorphous and crystalline forms (QHCl-AC)--in solid phase.
作者信息
Stanisz Beata
机构信息
Department of Pharmaceutical Chemistry, University of Medical Sciences, 6 Grunwaldzka Str., 60-780 Poznań, Poland.
出版信息
Acta Pol Pharm. 2003 Nov-Dec;60(6):443-9.
The first-order rate constants and thermodynamic parameters (Ea [kJ x mole(-1)] = 139.9 for RH=0% and 133.6 for RH=76.4%; deltaH(++)[kJ x mole(-1) = 137.4 for RH=0% and 131.1 for RH=76.4%; delta(S(++) [J x (K(-1) x mole(-1)) = 35.4 for RH=0% and -207.8 for RH=76.4% for the degradation of quinapril hydrochloride--a mixture of amorphous and crystalline forms (QHCl-AC) in solid state were calculated. The effect of humidity on the stahility of QHCl-AC in the humidity range 25.0% to 76% at 363K is described by the equation ln ki = ax + b = (0.058 +/- 0.0086) x RH% - (14.19 +/- 0.50). Mechanism of degradation of QHCl-AC was investigated at 363 K (relative humidity 76.4%) and 373 K (relative humidity 0%).
计算了盐酸喹那普利——无定形和结晶形式的混合物（QHCl - AC）固态降解的一级速率常数和热力学参数（对于RH = 0%，Ea [kJ·mol⁻¹] = 139.9；对于RH = 76.4%，Ea [kJ·mol⁻¹] = 133.6；对于RH = 0%，ΔH⁺⁺ [kJ·mol⁻¹] = 137.4；对于RH = 76.4%，ΔH⁺⁺ [kJ·mol⁻¹] = 131.1；对于RH = 0%，ΔS⁺⁺ [J·(K⁻¹·mol⁻¹)] = 35.4；对于RH = 76.4%，ΔS⁺⁺ [J·(K⁻¹·mol⁻¹)] = - 207.8）。湿度对363K下25.0%至76%湿度范围内QHCl - AC稳定性的影响由方程ln ki = ax + b = (0.058 ± 0.0086)×RH% - (14.19 ± 0.50)描述。在363K（相对湿度76.4%）和373K（相对湿度0%）下研究了QHCl - AC的降解机制。
Zotero 插件