Structural Genomics Consortium, Karolinska Institutet, Department of Medical Biochemistry and Biophysics, 171 77 Stockholm, Sweden.
Exp Cell Res. 2010 May 1;316(8):1332-8. doi: 10.1016/j.yexcr.2010.02.041. Epub 2010 Mar 6.
The field of structural genomics emerged as one of many 'omics disciplines more than a decade ago, and a multitude of large scale initiatives have been launched across the world. Development and implementation of methods for high-throughput structural biology represents a common denominator among different structural genomics programs. From another perspective a distinction between "biology-driven" versus "structure-driven" approaches can be made. This review outlines the general themes of structural genomics, its achievements and its impact on biomedicine and drug discovery. The growing number of high resolution structures of known and potential drug target proteins is expected to have tremendous value for future drug discovery programs. Moreover, the availability of large numbers of purified proteins enables generation of tool reagents, such as chemical probes and antibodies, to further explore protein function in the cell.
结构基因组学作为“组学”领域的一个分支，在十多年前应运而生，世界各地已经启动了许多大规模的项目。高通量结构生物学方法的开发和应用是不同结构基因组学项目的共同基础。从另一个角度来看，可以将“生物学驱动”与“结构驱动”方法区分开来。本文综述了结构基因组学的主题、成就及其对生物医学和药物发现的影响。随着越来越多的已知和潜在药物靶点蛋白的高分辨率结构的出现，预计它们将对未来的药物发现计划具有巨大的价值。此外，大量纯化蛋白的可用性使得能够生成工具试剂，如化学探针和抗体，以进一步探索细胞内的蛋白质功能。
