Rigden Daniel J
School of Biological Sciences, University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7ZB, UK.
Curr Opin Biotechnol. 2006 Oct;17(5):457-64. doi: 10.1016/j.copbio.2006.07.004. Epub 2006 Aug 4.
Structural genomics programs are only now moving into the large-scale production phase, yet have already produced around 2000 protein structures. Through a widespread if not exclusive emphasis on structural novelty, our knowledge of the protein fold universe is improving rapidly. With this information comes the challenge of structure-based function annotation for the many target proteins about which little or nothing is known. Recent years have therefore seen the emergence of impressively diverse bioinformatics approaches to predict the function of a protein structure. Attention is now turning to means of combining these predictions with information from various other sources.
结构基因组学项目目前才刚刚进入大规模生产阶段，但已经产生了约2000个蛋白质结构。通过广泛（即便并非唯一）地强调结构新颖性，我们对蛋白质折叠类型的了解正在迅速增加。随着这些信息的出现，对于许多知之甚少或一无所知的目标蛋白质，基于结构的功能注释面临着挑战。因此，近年来出现了令人印象深刻的各种生物信息学方法来预测蛋白质结构的功能。现在人们的注意力正转向将这些预测与来自各种其他来源的信息相结合的方法。
