Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Kuopio, PO Box 1627, FI-70211 Kuopio, Finland.
Neuroimage. 2010 Jun;51(2):521-30. doi: 10.1016/j.neuroimage.2010.02.077. Epub 2010 Mar 6.
The aim of this study was to explore non-invasive imaging methods to detect post-injury structural axonal plasticity. Brain injury was launched by status epilepticus induced by intraperitoneal injection of either kainic acid or pilocarpine. Several months later, ex vivo diffusion tensor magnetic resonance imaging (DTI) showed increased FA in the dentate gyrus of both kainic acid (p<0.01) and pilocarpine animals (p<0.01). Importantly, FA changes correlated (p<0.01) with histologically verified axonal plasticity of myelinated and non-myelinated neuronal fibers. The changes observed in DTI parameters ex vivo in the septal dentate gyrus were also seen by in vivo DTI. As DTI is completely a non-invasive imaging method, these results may pave the way for non-invasive in vivo imaging of axonal plasticity after brain insults.
本研究旨在探索非侵入性成像方法以检测损伤后结构轴突的可塑性。脑损伤由腹腔内注射海人酸或匹罗卡品诱导的癫痫持续状态引起。数月后，离体扩散张量磁共振成像（DTI）显示海人酸（p<0.01）和匹罗卡品动物（p<0.01）的齿状回 FA 增加。重要的是，FA 变化与组织学验证的有髓和无髓神经元纤维的轴突可塑性相关（p<0.01）。在隔区齿状回中离体 DTI 观察到的参数变化也可通过体内 DTI 观察到。由于 DTI 是一种完全非侵入性的成像方法，这些结果可能为脑损伤后轴突可塑性的非侵入性体内成像铺平道路。
Zotero 插件