Persell Stephen D, Zei Charles, Cameron Kenzie A, Zielinski Michael, Lloyd-Jones Donald M
Northwestern University, Chicago, IL 60611, USA.
Arch Intern Med. 2010 Mar 8;170(5):470-7. doi: 10.1001/archinternmed.2009.525.
Data are sparse regarding how physicians use coronary risk information for prescribing decisions.
We presented 5 primary prevention scenarios to primary care physicians affiliated with an academic center and surveyed their responses after they were provided with (1) patient risk factor information, (2) 10-year estimated coronary disease risk information, and (3) 10-year and lifetime risk estimates. We asked about aspirin prescribing, lipid testing, and lipid-lowering drug prescribing.
Of 202 physicians surveyed, 99 (49%) responded. The physicians made guideline-concordant aspirin decisions 51% to 91% of the time using risk factor information alone. Providing 10-year risk estimates increased concordant aspirin prescribing when the 10-year coronary risk was moderately high (15%) and decreased guideline-discordant prescribing when the 10-year risk was low (2 of 4 cases). Providing the lifetime risk information sometimes increased guideline-discordant aspirin prescribing. The physicians selected guideline-concordant thresholds for initiating treatment with lipid-lowering drugs 44% to 75% of the time using risk factor information alone. Selecting too low or too high low-density lipoprotein cholesterol thresholds was common. Ten-year risk information improved concordance when the 10-year risk was moderately high. Providing lifetime risk information increased willingness to initiate pharmacotherapy at low-density lipoprotein cholesterol levels that were lower than those recommended by guidelines when the 10-year risk was low but the lifetime risk was high.
Providing 10-year coronary risk information improved some hypothetical aspirin-prescribing decisions and improved lipid management when the short-term risk was moderately high. High lifetime risk sometimes led to more intensive prescription of aspirin or lipid-lowering medication. This outcome suggests that, to maximize the benefits of risk-calculating tools, specific guideline recommendations should be provided along with risk estimates.
关于医生如何利用冠状动脉风险信息进行处方决策的数据很少。
我们向一家学术中心的初级保健医生展示了5种一级预防方案,并在向他们提供了(1)患者风险因素信息、(2)10年估计冠心病风险信息和(3)10年及终生风险估计后,调查了他们的反应。我们询问了阿司匹林处方、血脂检测和降脂药物处方情况。
在接受调查的202名医生中,99名(49%)做出了回应。医生仅使用风险因素信息时,51%至91%的时间做出了符合指南的阿司匹林决策。当10年冠状动脉风险中度较高(15%)时,提供10年风险估计增加了符合指南的阿司匹林处方,而当10年风险较低时(4例中的2例),减少了不符合指南的处方。提供终生风险信息有时会增加不符合指南的阿司匹林处方。医生仅使用风险因素信息时,44%至75%的时间选择了符合指南的启动降脂药物治疗阈值。选择过低或过高的低密度脂蛋白胆固醇阈值很常见。当10年风险中度较高时,10年风险信息提高了一致性。当10年风险较低但终生风险较高时,提供终生风险信息增加了在低于指南推荐水平的低密度脂蛋白胆固醇水平启动药物治疗的意愿。
当短期风险中度较高时,提供10年冠状动脉风险信息改善了一些假设的阿司匹林处方决策并改善了血脂管理。高终生风险有时会导致更积极地开具阿司匹林或降脂药物处方。这一结果表明,为了使风险计算工具的益处最大化,应在提供风险估计的同时提供具体的指南建议。