Ann Intern Med. 2009 Mar 17;150(6):396-404. doi: 10.7326/0003-4819-150-6-200903170-00008.
DESCRIPTION: Update of the 2002 U.S. Preventive Services Task Force (USPSTF) recommendation about the use of aspirin for the prevention of coronary heart disease. METHODS: Review of the literature since 2002, focusing on new evidence on the benefits and harms of aspirin for the primary prevention of cardiovascular disease, including myocardial infarction and stroke. The new evidence was reviewed and synthesized according to sex. RECOMMENDATIONS: Encourage men age 45 to 79 years to use aspirin when the potential benefit of a reduction in myocardial infarctions outweighs the potential harm of an increase in gastrointestinal hemorrhage. (A recommendation) Encourage women age 55 to 79 years to use aspirin when the potential benefit of a reduction in ischemic strokes outweighs the potential harm of an increase in gastrointestinal hemorrhage. (A recommendation) Evidence is insufficient to assess the balance of benefits and harms of aspirin for cardiovascular disease prevention in men and women 80 years or older. (I statement) Do not encourage aspirin use for cardiovascular disease prevention in women younger than 55 years and in men younger than 45 years. (D recommendation).
描述：更新2002年美国预防服务工作组（USPSTF）关于使用阿司匹林预防冠心病的建议。 方法：回顾2002年以来的文献，重点关注阿司匹林用于心血管疾病一级预防（包括心肌梗死和中风）的益处和危害的新证据。根据性别对新证据进行了回顾和综合分析。 建议：当降低心肌梗死的潜在益处超过增加胃肠道出血的潜在危害时，鼓励45至79岁的男性使用阿司匹林。（A级建议）当降低缺血性中风的潜在益处超过增加胃肠道出血的潜在危害时，鼓励55至79岁的女性使用阿司匹林。（A级建议）证据不足，无法评估80岁及以上男性和女性使用阿司匹林预防心血管疾病的利弊平衡。（I类声明）不鼓励55岁以下女性和45岁以下男性使用阿司匹林预防心血管疾病。（D级建议）
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