Tham Clement C Y, Kwong Yolanda Y Y, Leung Dexter Y L, Lam Sze Wing, Li Felix C H, Chiu Thomas Y H, Chan Jonathan C H, Lam Dennis S C, Lai Jimmy S M
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle St, Kowloon, Hong Kong, China.
Arch Ophthalmol. 2010 Mar;128(3):303-11. doi: 10.1001/archophthalmol.2010.12.
To compare the complications of phacoemulsification alone vs combined phacotrabeculectomy in chronic angle-closure glaucoma (CACG) with coexisting cataract.
Patients with CACG with coexisting cataract recruited into 2 randomized controlled trials comparing phacoemulsification alone vs combined phacotrabeculectomy were pooled for analysis. The first trial recruited patients with medically controlled intraocular pressure, while the second trial recruited patients with medically uncontrolled intraocular pressure. The 2 trials had otherwise identical study designs. All patients were reviewed every 3 months for 2 years after surgery. The main outcome measure was the surgical complications of phacoemulsification alone vs combined phacotrabeculectomy in CACG eyes with cataract.
One hundred twenty-three CACG eyes with cataract from 123 patients were included. Sixty-two CACG eyes were randomized to receive phacoemulsification alone, and 61 eyes had combined phacotrabeculectomy. In the phacoemulsification group, 5 of the 62 CACG eyes (8.1%) had a total of 5 surgical complications. In the combined phacotrabeculectomy group, 16 of the 61 CACG eyes (26.2%) had a total of 19 surgical complications. The difference in the proportion of eyes with 1 or more surgical complications between the 2 treatment groups was statistically significant (P = .007, Pearson chi(2) test). There was no statistically significant difference in final visual acuity or glaucomatous progression during the 24-month follow-up.
Combined phacotrabeculectomy resulted in significantly more surgical complications than phacoemulsification alone in CACG eyes with coexisting cataract. There was no difference in visual acuity or disease progression between the 2 treatment groups.
比较单纯超声乳化术与超声乳化小梁切除术联合治疗慢性闭角型青光眼(CACG)合并白内障的并发症。
将纳入两项比较单纯超声乳化术与超声乳化小梁切除术联合治疗的随机对照试验的CACG合并白内障患者进行汇总分析。第一项试验纳入眼压经药物控制的患者,第二项试验纳入眼压经药物治疗未得到控制的患者。两项试验的研究设计在其他方面相同。所有患者术后每3个月复查一次,共复查2年。主要观察指标为单纯超声乳化术与超声乳化小梁切除术联合治疗CACG合并白内障患者的手术并发症。
纳入了123例患者的123只CACG合并白内障眼。62只CACG眼被随机分配接受单纯超声乳化术,61只眼接受超声乳化小梁切除术联合治疗。在单纯超声乳化术组,62只CACG眼中有5只(8.1%)共出现5种手术并发症。在超声乳化小梁切除术联合治疗组,61只CACG眼中有16只(26.2%)共出现19种手术并发症。两组间出现1种或更多手术并发症的眼比例差异具有统计学意义(P = .007,Pearson卡方检验)。在24个月的随访期间,最终视力或青光眼进展方面无统计学显著差异。
在CACG合并白内障眼中,超声乳化小梁切除术联合治疗导致的手术并发症明显多于单纯超声乳化术。两组间视力或疾病进展无差异。