Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, 4/F Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong SAR, The People's Republic of China.
Hong Kong Eye Hospital, Kowloon, Hong Kong SAR, The People's Republic of China.
Sci Rep. 2021 Nov 30;11(1):23136. doi: 10.1038/s41598-021-02296-x.
To investigate the peripapillary vascular metrics in early normal tension glaucoma (NTG) and early primary angle closure glaucoma (PACG) eyes using optical coherence tomography angiography (OCT-A). One or both eyes of each subject were imaged for a 3 × 3 mm peripapillary region by swept-source OCT-A (DRI-OCT Triton, Topcon, Japan) and assessed by an automated MATLAB program. OCT-A metrics including circumpapillary vessel density (cpVD) and fractal dimension (cpFD) were compared. Their association with visual field (VF) parameters and retinal nerve fiber layer (RNFL) thickness were determined. Sixty-eight eyes of 51 PACG, 68 eyes of 48 NTG, and 68 eyes of 49 control subjects were cross-sectionally analyzed. NTG eyes had significantly lower global cpVD (52.369 ± 0.781%) compared with PACG eyes (55.389 ± 0.721%, P = 0.004) that had comparable disease severity and average RNFL thickness. Multivariable analysis revealed that, for PACG and NTG eyes, decreased cpVD ([PACG] β = -4.242; CI: -8.120, -0.363 vs [NTG] β = -5.531; CI: -9.472, -1.590) and cpFD ([PACG] β = -8.894;CI: -11.925, -5.864 vs [NTG] β = -12.064; CI: -17.095, -6.932) were associated with decreased RNFL thickness (all P ≤ 0.032); with a stronger association between decrease cpFD and decreased RNFL thickness in NTG eyes (P = 0.028). Decreased cpVD was associated with decrease mean deviation (MD) in NTG eyes (β = -0.707; CI: -1.090, -0.324; P ≤ 0.001) and not associated with the visual field parameters in PACG eyes. Early NTG had lower global cpVD compared with early PACG, despite similar disease severity and average RNFL thickness.
使用光相干断层扫描血管造影术 (OCT-A) 研究早期正常眼压青光眼 (NTG) 和早期原发性闭角型青光眼 (PACG) 患者的视盘周围血管指标。通过扫频源 OCT-A (DRI-OCT Triton，Topcon，日本) 对每个受试者的一只或两只眼睛进行 3 × 3 毫米视盘周围区域成像，并由自动 MATLAB 程序进行评估。比较了 OCT-A 指标，包括环周血管密度 (cpVD) 和分形维数 (cpFD)。确定它们与视野 (VF) 参数和视网膜神经纤维层 (RNFL) 厚度的关系。对 51 例 PACG 的 68 只眼、48 例 NTG 的 68 只眼和 49 例对照者的 68 只眼进行了横断面分析。与 PACG 眼 (55.389 ± 0.721%) 相比，NTG 眼的全 cpVD (52.369 ± 0.781%) 明显较低，尽管疾病严重程度和平均 RNFL 厚度相当。多变量分析显示，对于 PACG 和 NTG 眼，cpVD 降低 ([PACG] β = -4.242；CI：-8.120，-0.363 与 [NTG] β = -5.531；CI：-9.472，-1.590) 和 cpFD ([PACG] β = -8.894；CI：-11.925，-5.864 与 [NTG] β = -12.064；CI：-17.095，-6.932) 与 RNFL 厚度降低相关（所有 P ≤ 0.032）；NTG 眼中 cpFD 降低与 RNFL 厚度降低之间的相关性更强（P = 0.028）。NTG 眼中 cpVD 降低与平均偏差 (MD) 降低相关（β = -0.707；CI：-1.090，-0.324；P ≤ 0.001），而与 PACG 眼中的视野参数无关。尽管疾病严重程度和平均 RNFL 厚度相似，但早期 NTG 的全 cpVD 仍低于早期 PACG。
