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Parkinson disease: ADAGIO trial hints that rasagiline slows disease progression.

作者信息

Sampaio Cristina, Ferreira Joaquim J

出版信息

Nat Rev Neurol. 2010 Mar;6(3):126-8. doi: 10.1038/nrneurol.2010.2.

DOI:10.1038/nrneurol.2010.2
PMID:20212427
Abstract
摘要

相似文献

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Parkinson disease: ADAGIO trial hints that rasagiline slows disease progression.帕金森病：ADAGIO试验提示雷沙吉兰可减缓疾病进展。
Nat Rev Neurol. 2010 Mar;6(3):126-8. doi: 10.1038/nrneurol.2010.2.
2
Combined rasagiline and antidepressant use in Parkinson disease in the ADAGIO study: effects on nonmotor symptoms and tolerability.ADAGIO 研究中帕金森病中联合使用雷沙吉兰和抗抑郁药：对非运动症状和耐受性的影响。
JAMA Neurol. 2015 Jan;72(1):88-95. doi: 10.1001/jamaneurol.2014.2472.
3
Symptomatic efficacy of rasagiline monotherapy in early Parkinson's disease: post-hoc analyses from the ADAGIO trial.雷沙吉兰单药治疗早期帕金森病的症状疗效：来自ADAGIO试验的事后分析
Parkinsonism Relat Disord. 2014 Jun;20(6):640-3. doi: 10.1016/j.parkreldis.2014.02.024. Epub 2014 Mar 5.
4
[Rasagiline is not for all Parkinson disease patients: the ADAGIO study].[雷沙吉兰并非适用于所有帕金森病患者：ADAGIO研究]
Ned Tijdschr Geneeskd. 2010;154:A2496.
5
[Rasagiline in Parkinson's disease].[雷沙吉兰治疗帕金森病]
Neurologia. 2008 May;23(4):238-45.
6
[Rasagiline in motor fluctuations].
Fortschr Neurol Psychiatr. 2005 Sep;73(9):488.
7
Rasagiline. Parkinson's disease: a simple me-too.雷沙吉兰。帕金森病：一种简单的仿制药。
Prescrire Int. 2006 Dec;15(86):220.
8
Rasagiline -- is there a place for this drug in managing Parkinson's disease?
Int J Clin Pract. 2006 Feb;60(2):132-3. doi: 10.1111/j.1742-1241.2006.00843d.x.
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Rasagiline as a therapy for Parkinson's disease (PD).雷沙吉兰作为帕金森病（PD）的一种治疗方法。
Am J Geriatr Pharmacother. 2007 Jun;5(2):174-5; author reply 175-6. doi: 10.1016/j.amjopharm.2007.06.002.
10
A double-blind, delayed-start trial of rasagiline in Parkinson's disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes.一项针对帕金森病的雷沙吉兰双盲、延迟启动试验（ADAGIO 研究）：对额外治疗需求、UPDRS 评分变化和非运动结果的预先指定和事后分析。
Lancet Neurol. 2011 May;10(5):415-23. doi: 10.1016/S1474-4422(11)70073-4. Epub 2011 Apr 7.

引用本文的文献

1
Disease modification and Neuroprotection in neurodegenerative disorders.神经退行性疾病中的疾病修饰与神经保护
Transl Neurodegener. 2017 Sep 26;6:25. doi: 10.1186/s40035-017-0096-2. eCollection 2017.
2
MAO-inhibitors in Parkinson's Disease.MAO 抑制剂在帕金森病中的应用。
Exp Neurobiol. 2011 Mar;20(1):1-17. doi: 10.5607/en.2011.20.1.1. Epub 2011 Mar 31.
3
Multiple system atrophy: a clinical and neuropathological perspective.多系统萎缩：临床与神经病理学视角。

本文引用的文献

1
The delayed-start study design.延迟启动研究设计。
N Engl J Med. 2009 Sep 24;361(13):1304-6. doi: 10.1056/NEJMsm0904209.
2
A double-blind, delayed-start trial of rasagiline in Parkinson's disease.雷沙吉兰治疗帕金森病的双盲、延迟启动试验。
N Engl J Med. 2009 Sep 24;361(13):1268-78. doi: 10.1056/NEJMoa0809335.
3
Biomarkers for Parkinson's [corrected] disease: tools to assess Parkinson's disease onset and progression.帕金森病的生物标志物：评估帕金森病发病和进展的工具。 [已修正]
Trends Neurosci. 2011 Nov;34(11):581-90. doi: 10.1016/j.tins.2011.08.003. Epub 2011 Sep 29.
4
Tapping natural reservoirs of homing endonucleases for targeted gene modification.利用天然归巢内切酶库进行靶向基因修饰。
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13077-82. doi: 10.1073/pnas.1107719108. Epub 2011 Jul 22.
5
Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's disease.单胺氧化酶B抑制剂治疗帕金森病的疗效、安全性及患者偏好性
Patient Prefer Adherence. 2011 Jan 20;5:57-64. doi: 10.2147/PPA.S11182.
6
Discordant effects of rasagiline doses in Parkinson disease.
Nat Rev Neurol. 2010 Jul;6(7):1p following 410. doi: 10.1038/nrneurol.2010.2-c1.
Ann Neurol. 2008 Dec;64 Suppl 2:S111-21. doi: 10.1002/ana.21602.
4
Long-term outcome of early versus delayed rasagiline treatment in early Parkinson's disease.早期帕金森病中早期与延迟使用雷沙吉兰治疗的长期结果
Mov Disord. 2009 Mar 15;24(4):564-73. doi: 10.1002/mds.22402.
5
Monoamine oxidase B inhibitors for early Parkinson's disease.用于早期帕金森病的单胺氧化酶B抑制剂
Cochrane Database Syst Rev. 2005 Jul 20;2005(3):CD004898. doi: 10.1002/14651858.CD004898.pub2.
6
Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives.抗帕金森病药物雷沙吉兰及其衍生物的神经保护作用机制。
Brain Res Brain Res Rev. 2005 Apr;48(2):379-87. doi: 10.1016/j.brainresrev.2004.12.027.
7
A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease.雷沙吉兰用于早期帕金森病的一项对照、随机、延迟启动研究。
Arch Neurol. 2004 Apr;61(4):561-6. doi: 10.1001/archneur.61.4.561.
8
Treatment interventions for Parkinson's disease: an evidence based assessment.帕金森病的治疗干预措施：基于证据的评估。
Lancet. 2002 May 4;359(9317):1589-98. doi: 10.1016/S0140-6736(02)08520-3.
9
Slowing the progression of Alzheimer disease: methodologic issues.延缓阿尔茨海默病的进展：方法学问题
Alzheimer Dis Assoc Disord. 1997;11 Suppl 5:S10-21; discussion S37-9.