Pediatric Center of Cardiac Surgery, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, 100037, Beijing, China.
Lung. 2010 Jun;188(3):179-89. doi: 10.1007/s00408-010-9233-8. Epub 2010 Mar 6.
Advanced pulmonary arterial hypertension is characterized by extensive vascular remodeling that is usually resistant to vasodilator therapy. As the major component of the vascular media, decreased apoptosis of pulmonary arterial smooth muscle cell (PASMC) plays key roles during pulmonary vascular remodeling. Recent studies showed that enhancement of apoptosis of PASMC can reverse pulmonary vascular remodeling and severe pulmonary arterial hypertension. Enhancement of apoptosis of PASMC is becoming a novel strategy to reverse severe pulmonary arterial hypertension. This review analyzes some potential strategies to reverse pulmonary vascular remodeling.
特发性肺动脉高压的特征是广泛的血管重构，通常对血管扩张剂治疗有抗性。作为血管中层的主要成分，肺动脉平滑肌细胞（PASMC）的凋亡减少在肺血管重构中起着关键作用。最近的研究表明，增强 PASMC 的凋亡可以逆转肺血管重构和严重的肺动脉高压。增强 PASMC 的凋亡正在成为逆转严重肺动脉高压的一种新策略。本综述分析了一些逆转肺血管重构的潜在策略。
