Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland.
Eur Child Adolesc Psychiatry. 2010 Mar;19(3):227-35. doi: 10.1007/s00787-010-0087-7. Epub 2010 Mar 6.
Obsessive-compulsive disorder (OCD) is characterized by recurrent, intrusive and disturbing thoughts as well as by repetitive stereotypic behaviors. Epidemiological data are similar in children and adults, i.e., between 1 and 3% of the general population suffer from OCD. Children with OCD are often seriously impaired in their development. OCD, especially of early onset, has been shown to be familial. Several candidate genes of predominantly neurotransmitter systems have been analyzed and a total of three genome-wide linkage scans have been performed until now. Analyses of candidate genes in linkage regions have not provided evidence for their involvement in OCD, with the exception of the glutamate transporter gene SLC1A1 on 9p24. Genome-wide association analyses are in progress and the results will promote further independent replication studies. The consideration of subtypes regarding age of onset, symptom dimensions and/or comorbid disorders is needed.
强迫症（OCD）的特征是反复出现、侵入性和令人不安的想法以及重复的刻板行为。儿童和成人的流行病学数据相似，即 1%至 3%的普通人群患有 OCD。患有 OCD 的儿童在发育过程中经常受到严重影响。已经表明 OCD，尤其是早期发病，具有家族性。已经分析了主要涉及神经递质系统的几个候选基因，并且迄今为止已经进行了总共三次全基因组连锁扫描。在连锁区域中对候选基因的分析并未提供其参与 OCD 的证据，谷氨酸转运体基因 SLC1A1 除外，该基因位于 9p24 上。全基因组关联分析正在进行中，结果将促进进一步的独立复制研究。需要考虑亚型，包括发病年龄、症状维度和/或合并症。
