Max Planck UCL Centre for Computational Psychiatry and Ageing Research, London, UK.
Wellcome Centre for Human Neuroimaging, University College London, London, UK.
Curr Top Behav Neurosci. 2021;49:17-30. doi: 10.1007/7854_2020_195.
OCD most often arises before adulthood with adolescence being a particularly vulnerable period. This is also a time when both brain and cognition undergo fundamental developmental change and reorganisation. However, the neurocognitive mechanisms that drive the emergence of OCD during development are still largely unknown. In this chapter, I review the relatively sparse literature on the developmental aspects of OCD and I discuss the symptomatic, cognitive and neural patterns in OCD and the developing mind. I highlight how we need to understand the emergence of cognitive impairments and neural alteration in a developmental context if we want to understand more about the mechanisms that give rise to OCD. Moreover, I outline how we best approach this challenge to overcome the current limitations in research.
强迫症大多在成年前出现，青春期是一个特别脆弱的时期。这也是大脑和认知经历根本发育变化和重组的时候。然而，在发育过程中导致强迫症出现的神经认知机制在很大程度上仍然未知。在本章中，我回顾了关于强迫症发展方面的相对较少的文献，并讨论了强迫症和发育中大脑的症状、认知和神经模式。我强调了如果我们要了解导致强迫症的机制，就需要在发展背景下理解认知障碍和神经改变的出现。此外，我概述了如何最好地应对这一挑战，以克服目前研究的局限性。
